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西魏文帝大统大统七年(541年),仚定举兵犯西魏。北魏命将领独孤信讨伐,魏军未至而仚定已先为部下所杀。仚定的部众被独孤信击败后,弥定被西魏另立为宕昌王。
大统十六年(550年),弥定受到同族的酋长梁獠甘袭击因此逃奔西魏,梁獠甘自立为宕昌王。西魏丞相宇文泰命将领宇文贵、豆卢甯、史甯等率兵讨伐獠甘,将之擒获并斩首,重迎弥定回到宕昌。
北周灭西魏后,北周武帝保定初年,弥定遣使向北周贡献方物。保定三年(563年),又遣使贡献猛兽。保定四年(564年),弥定侵犯北周的洮州,被北周将领李贤打败。同年,弥定又引吐谷浑军侵犯北周,再被李贤打败。北周武帝大怒,命大将田弘讨灭宕昌国,在原地设立宕州,宕昌国自此灭亡。至于弥定的下场,史籍并未记载。
Western Wei and Northern Zhou destroyed after the early years of the North of Baoding Yu Wen Yong, Zhou Mi will contribute to dispatch his envoy to north side property. Baoding three years (563 years), they sent envoys contribution to the beast. Baoding four years (564 years), Mi Zhou of the Tao be violating state and the Northern Zhou Dynasty general Li Xian was defeated. In the same year, Mi will also cited violations of the Northern Zhou Dynasty Tuyuhun Army, then defeated by Li Xian. North Yu Wen Yong furious, Tien Hung-life general discussion off Dangchang States, set up dawdle in situ state, since extinction Dangchang country. The indemnity given end, history books are not recorded.