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西魏文帝大統大統七年(541年),仚定舉兵犯西魏。北魏命將領獨孤信討伐,魏軍未至而仚定已先為部下所殺。仚定的部衆被獨孤信擊敗後,彌定被西魏另立為宕昌王。
大統十六年(550年),彌定受到同族的酋長梁獠甘襲擊因此逃奔西魏,梁獠甘自立為宕昌王。西魏丞相宇文泰命將領宇文貴、豆盧甯、史甯等率兵討伐獠甘,將之擒獲並斬首,重迎彌定回到宕昌。
北周滅西魏後,北周武帝保定初年,彌定遣使嚮北周貢獻方物。保定三年(563年),又遣使貢獻猛獸。保定四年(564年),彌定侵犯北周的洮州,被北周將領李賢打敗。同年,彌定又引吐𠔌渾軍侵犯北周,再被李賢打敗。北周武帝大怒,命大將田弘討滅宕昌國,在原地設立宕州,宕昌國自此滅亡。至於彌定的下場,史籍並未記載。
Western Wei and Northern Zhou destroyed after the early years of the North of Baoding Yu Wen Yong, Zhou Mi will contribute to dispatch his envoy to north side property. Baoding three years (563 years), they sent envoys contribution to the beast. Baoding four years (564 years), Mi Zhou of the Tao be violating state and the Northern Zhou Dynasty general Li Xian was defeated. In the same year, Mi will also cited violations of the Northern Zhou Dynasty Tuyuhun Army, then defeated by Li Xian. North Yu Wen Yong furious, Tien Hung-life general discussion off Dangchang States, set up dawdle in situ state, since extinction Dangchang country. The indemnity given end, history books are not recorded.