病入骨髓

Explanation: Disease to the bone. Describe an illness serious, incurable. Also used to refer serious cases, can not be saved. 　　Source: "Han Fei Yu old" disease management in the Cou, Tom pressed the reach of him; in the skin, technetium reach of stone also; in the stomach, the reach of the fire is also homogeneous; in the bone marrow, Siming of belonging, what are helpless. Today in the bone marrow, Robinson is not invited too. "