后古典期（约1000～1520）的文化有浓厚的墨西哥风格。从墨西哥南下的托尔特克人征服尤卡坦，并以奇琴伊察为都城。建筑中出现石廊柱群及以活人为祭品的“圣井”、球场，还有观察天象的天文台和目前保存最完整的高大的金字塔式台庙，崇拜羽蛇神魁扎尔科亚特尔。此后北部的玛雅潘取代奇琴伊察成为后古典期文化的中心。这一时期的陶器和雕刻艺术都较粗糙，世俗文化兴起，并带来好战之风。玛雅潘的统治者与其他城邦结成联盟，用武力建立起自己的统治。1450年，大概由于内部叛乱，玛雅科潘被焚毁，此后百年中文化趋于衰落。1523～1524年，西班牙殖民者乘虚而入，从墨西哥南下，占领尤卡坦半岛，玛雅文明被彻底破坏。
The Postclassic (beginning AD 900-1000, depending on area) is, like the Late Classic, characterized by the cyclical crystallization and fragmentation of various polities. The main Maya centers were located in the northern lowlands. Following Chichén Itzá, whose political structure collapsed during the Early Postclassic, Mayapán rose to prominence during the Middle Postclassic and dominated the north for ca. 200 years. After Mayapán’s fragmentation, political structure in the northern lowlands revolved around a number of large towns or city-states, such as Oxkutzcab and Ti’ho (Mérida, Yucatán), that competed with one another.
Toniná, in the Chiapas highlands, and Kaminaljuyú in the central Guatemala highlands, were important southern highland Maya centers. The latter site, Kaminaljuyú, is one of the longest occupied sites in Mesoamerica and was continuously inhabited from ca. 800 BC to around AD 1200. Other important highland Maya groups include the K'iche' of Utatlán, the Mam in Zaculeu, the Poqomam in Mixco Viejo, and the Kaqchikel at Iximche in the Guatemalan highlands. The Pipil resided in El Salvador, while the Ch'orti' were in eastern Guatemala and northwestern Honduras.
In central Mexico, the early portion of the Postclassic correlates with the rise of the Toltec and an empire based at their capital, Tula (also known as Tollan). Cholula, initially an important Early Classic center contemporaneous with Teotihuacan, maintained its political structure (it did not collapse) and continued to function as a regionally important center during the Postclassic. The latter portion of the Postclassic is generally associated with the rise of the Mexica and the Aztec empire. One of the more commonly known cultural groups in Mesoamerica, the Aztec politically dominated nearly all of central Mexico, the Gulf Coast, Mexico’s southern Pacific Coast (Chiapas and into Guatemala), Oaxaca, and Guerrero.
The Tarascans (also known as the P'urhépecha) were located in Michoacan and Guerrero. With their capital at Tzintzuntzan, the Tarascan state was one of the few to actively and continuously resist Aztec domination during the Late Postclassic. Other important Postclassic cultures in Mesoamerica include the Totonac along the eastern coast (in the modern-day states of Veracruz, Puebla, and Hidalgo). The Huastec resided north of the Totonac, mainly in the modern-day states of Tamaulipas and northern Veracruz. The Mixtec and Zapotec cultures, centered at Mitla and Zaachila respectively, inhabited Oaxaca.
The Postclassic ends with the arrival of the Spanish and their subsequent conquest of the Aztec between 1519 and 1521. It should be noted that many other cultural groups did not acquiesce until later. For example, Maya groups in the Petén area, including the Itza at Tayasal and the Ko'woj at Zacpeten, remained independent until 1697.
Some Mesoamerican cultures never achieved dominant status or left impressive archeological remains but should be mentioned as noteworthy. These include the Otomi, Mixe-Zoque groups (which may or may not have been related to the Olmecs), the northern Uto-aztecan groups, often referred to as the Chichimeca, that include the Cora and Huichol, the Chontales, the Huaves, and the Pipil, Xincan and Lencan peoples of Central America.