Pasteurellosis
Pasteurella disease (pasteurellosis) is caused by the Pasteurella multocida an acute, febrile infectious diseases. Type of animal pasteurellosis often sepsis and acute hemorrhagic inflammation as the main feature, so in the past known as "hemorrhagic septicemia"; chronic form usually presents subcutaneous connective tissue, joints and various organs purulent lesions, and more mixed infection with other diseases or secondary.
One. Etiology
The disease's pathogen Pasteurella multocida. Hemolytic Pasteurella can also become sheep, cattle sepsis pathogens.
With specific capsular antigen (k antigen) adsorbed on red blood cells for passive hemagglutination test, divided into a, b, d, e IV serogroups; using cell antigen (o antigen) for the agglutination test, the points of the bacteria 12 serotypes. If k, o the two antigens together, so far, 16 serotypes. Disease, disease type, host specificity, pathogenicity, immunity, etc., with serotype related.
The bacteria can make chickens, ducks and other fowl cholera occurred, the pig lung disease occurs, so that all kinds of cattle, sheep, rabbits, horses, and many wild animals sepsis.
II. Epidemiology
Sick animals, diseased poultry droppings, secretions and contaminated animals are an important source of infection of this disease. The disease mainly through the digestive tract and respiratory tract, but also insects and damage by absorbing study of the skin, mucous membranes and infection. Many animals can be infected with the disease, animals in a variety of cattle, pigs, rabbits, sheep, more disease, goats, deer, camels, horses, donkeys, dogs, cats and mink, etc. can also be infected with the disease, but rarely reported. Poultry, chicken, turkey and ducks the most susceptible, geese, pigeons second. 20 kinds of wild birds have been infected with the disease reported. Incidence of young animals as much more serious, high mortality.
The occurrence of this disease in general no significant seasonal, but alternating hot and cold climate upheaval, hot, humid, rainy periods occur more. Temperature disorders, lowered immunity, the disease is one of the main predisposing factors. Another frequent long-distance transport or migration, fatigue, feed mutations, nutritional deficiencies, parasites often induce the disease. The presence of certain diseases caused by lower body resistance, easy secondary to the disease. Prevalence of the disease mostly local or distributed, the mutual transmission of the same species of animals of different species of animals also occasionally infect each other.
III. Pathogenesis
When the climate, seasonal changes, long-distance transport and parasitic infections, malnutrition and other factors have led to animal body resistance is lowered, the health carrier animals exist within the respiratory tract and tonsils of Pasteurella, will become a strong source of germs caused by the infection; addition to the contaminated feed, water, air, appliances and other digestive tract, respiratory tract, trauma caused by exogenous infection.
If the body resistance is weak, and strong when the invasion of germs, it will quickly through the lymph nodes to prevent the effect, into the bloodstream, the formation of bacteremia, infected animals can be killed at 24h internal sepsis. If the body resistance strength or the number of invasive bacterial organism virulence is not too much or too weak, extended duration of 1-2 days or longer. If the bacteria are attenuated force, the body also has a strong resistance to the disease will be confined to the local.
IV. Clinical symptoms
1. Avian pasteurellosis: also known as fowl cholera (fowl cholera) naturally infected with an incubation period of 2-9 days.
(1) chicken:
a. The most acute form: common in the early epidemic, the high egg-laying chickens in the most common. Chickens without premonitory symptoms in the evening as usual, very full to eat the next day incidence of death in the sheds in the farm.
b. Acute type: This type is most common, chickens mainly for depression, loose feathers, chaos, necking with eyes closed, head shrinking under the wings, reluctant to move, outliers Dai Li. Chickens often have diarrhea, discharge of yellow, white or green Xifen. Body temperature to 43 ~ 44 ℃, less food or do not eat, Keyu increase. Difficulty breathing, mouth, nasal secretions increase. Meat beard comb and bluish purple, and some swelling disease beard chicken, hot pain. Egg-laying hens to stop laying. Occurred last failure, coma and death, about a half-day short course, long 1 ~ 3d.
c. Chronic form: die by the change from acute, more common in the late pop. To chronic pneumonia, chronic respiratory inflammation and chronic gastroenteritis were more common. Sticky secretions of chickens out of the nose, swollen sinuses, throat and affect the respiratory secretions plot. Frequent diarrhea. Chickens weight loss, mental Weidun, crown pale. Some chickens bearded one or both marked swelling of the meat, then cheese-like substance may have a purulent, or dry, necrosis and shedding. Some chickens have arthritis, often restricted to the feet or wings at the joint and tendon sheath, manifested as joint swelling, pain, numbness toes, so on_set_ of claudication. Course of the disease can be towed more than a month, but the long-term growth and egg production can not be restored.
(2) duck: duck pasteurellosis commonly known as "blast shook his head."
(3) Other poultry
The symptoms of adult geese and ducks are similar Goose morbidity and mortality of adult geese than serious, often dominated by acute, mental Weidun, loss of appetite waste must, diarrhea, throat with a sticky discharge. Purple beak and webbed, and open spots conjunctival bleeding, duration of 1 ~ 2d is attributable to death.
Pigeon pasteurellosis oncoming acute severe illness, death fast, Bingge many do not eat, depression, necking eyes closed, feathers loose chaos, lay on one foot, body temperature above 42 ℃, thirst often drinking water, crop expansion Man, put down when the port light yellow viscous liquid flow, conjunctival flushing, nasal tumors lose their gray, and some Bingge diarrhea, white or green mucus discharge Xifen, duration 1-2 days.
Pasteurella disease occurs mainly in wild waterfowl in the flying geese head ducks, gulls which manifested as acute after a sudden death, from the habitat of the rock fall off after most of the performance of the sub-acute, systemic symptoms; there's duck performance blindness.
2. Swine pasteurellosis: also known as lung disease, incubation period is generally 1-14 days. According to the development of the disease can be divided into the most acute, three patients with acute and chronic type.
(1) the most acute form: often showed symptoms of sepsis, diseased body temperature suddenly rises to 4l ℃ -42 ℃, difficulty breathing, rapid heartbeat, not eating, mouth, nasal purple. Ears, neck, abdomen, bleeding, etc. erythema. Throat swelling, hard and hot; pigs and dogs were sitting potential death in a few hours to 1 day.
(2) acute-type: the pleura are often symptoms of pneumonia. Body temperature rose to about 40 ℃-4l ℃. Difficulty breathing, with short, dry cough, runny nose, asthma. Mucus or purulent conjunctivitis. Bleeding red skin purpura. The beginning of constipation, then diarrhea. 2-3 days, often in death, immortality and more become chronic.
(3) chronic type: performance on a continuous cough, shortness of breath. Pigs gradual weight loss, and sometimes joint swelling. Finally, persistent diarrhea, failure and died.
3. Bovine pasteurellosis: also known as bovine hemorrhagic septicemia, incubation period 2-5 days.
(1) defeated Blood: more common in Buffalo, the performance of high fever (4l ℃ -42 ℃), depression, conjunctival flushing, nose dry, do not eat, lactation and rumination to stop, abdominal pain, diarrhea, and early atherosclerotic dung, in liquid, after mixed with mucus, mucosal pieces and blood, with a stench, and often death in 12-24h.
(2) edema: a common yak, in addition to the performance of systemic symptoms, disease Tau, neck, throat and chest subcutaneous edema, finger pressing the early hot, hard, painful; after the cool, relieve pain, tongue and around organizations a high degree of swelling, salivation, breathing difficulties, eye irritation, tears, mucous membranes, cyanosis, diarrhea, often due to suffocation and death, disease, mostly 12-36h.
(3) pneumonia type: cow performance of acute fibrinous pleurisy, pneumonia symptoms. Some late diarrhea, then the blood, some blood in urine, died a few days to two weeks, and some become chronic type.
(4) chronic type: mainly to chronic pneumonia, duration of 1 month or more.
4. Sheep pasteurellosis:
(1) the most acute form: more common in breast-feeding a lamb, sudden on_set_, chills, weakness, shortness of breath, often within hours of death.
(2) Acute Type: Bing Yang depression, body temperature rose to 41 ~ 42 ℃, coughing, nose bleeding and mixed with mucus. Constipation in early disease, post-diarrhea, and some were bloody stool samples, and finally died of dehydration due to diarrhea.
(3) chronic type: Bing Yang weight loss, loss of appetite, coughing, difficulty breathing, extreme weight loss before death.
5. Rabbit pasteurellosis:
Pasteurella is caused by 9 weeks to 6 months of the most important cause of death in rabbits. Incubation period of varying lengths, generally from a few hours to 5 days or longer.
(1) hemorrhagic septicemia type: The most often no obvious symptoms of acute and sudden death. Production of the occurrence of rhinitis and pneumonia, sepsis most common mixture, can be expressed as the spirit of malaise, loss of appetite but no waste must, fever, nasal outflow of serous, mucinous, or purulent nasal discharge, and sometimes diarrhea. Before his death the temperature drops, the limbs twitch, the course hours to 3 days.
(2) type of infectious rhinitis: nasal outflow of serous, mucinous, or purulent secretions, difficulty breathing, sneezing, coughing, nasal crusting in the nostril, plug the nostrils, making breathing more difficult, and the emergence of grunt. Because patients often rabbit scratch claws grasp the nose can be bacteria into the eye, skin, etc., gives rise to other diseases. The general course of the disease ranging from several days to several months, treatment failure and death is not much time.
(3) local pneumonia type: often come from the secondary infectious rhinitis. Rex is very small because the amount of exercise, the natural incidence of pneumonia symptoms rarely seen until later when the performance of serious breathing difficulties. Rabbits suffering from loss of appetite, fever, depression, sometimes diarrhea or symptoms of joint swelling, and finally more severe because of pulmonary hemorrhage, necrosis, or sepsis and died.
(4) otitis media type: torticollis, also known as disease, is a bacteria spread to the inner ear and brain results. Its not the same degree skew the neck, the age of on_set_ is also inconsistent. Some newly weaned rabbit head and neck appeared skewed, but the majority of adult rabbits. Suffering from a serious rabbit, head tilt toward the party rolling until the stop is the object. The two can not face suffering from eating rabbits extremely difficult, and thus gradually thin. Course of varying lengths, and ultimately died because of failure.
(5) conjunctivitis type: clinical manifestations of tears, conjunctival congestion, swelling, eye discharge, often stick to the eyelid.
(6) abscesses, metritis and orchitis type: abscess can occur throughout the body. The beginning of subcutaneous abscess, skin irritation, induration, and later into a volatile abscess. Inflammation of the uterus, the maternal vaginal purulent discharge. Orchitis male rabbits can express one or both sides of the testicular swelling, and sometimes feel hot touch.
6. Equine pasteurellosis:
Equine pasteurellosis occurs mainly in the juvenile horse, donkey rare.
(1) paralysis type: Performance horse fever disease (40 ℃ above), depression, conjunctival flushing, increased pulse number, or completely unresponsive to the late hour, can not be retracted lip drooping, lay on, the front legs and outside, and hind legs stretched After the foreign party, knee touch the ground, lips sticks, the course of several hours to 2 days.
(2) edema: disease horse slightly higher temperature (40 ℃ or so), pulse increased the number of sensitive on both sides of the limbs and spine, in the cheek, lips, nose, neck and shoulders, etc. appear before the Department of inflammatory swelling.
(3) exciting type: found in the ass, showing slightly higher body temperature, chest inflammatory edema, often bite the chest, died shrieking, rolling, impact and other neurological symptoms, duration of 2-3 days.
7. Deer Pasteurellosis: incubation period 1-5 days, divided into two types.
(1) acute defeat Blood: the performance of severe systemic disease symptoms deer often die in 1-2 days.
(2) pneumonia type (breast shape): In addition to systemic symptoms of disease of deer, the performance of cough, respiratory Pocu, ataxia, severe cases of extreme difficulty breathing, head stretched forward, nose flap, froth at the mouth, thin fecal , generalized muscle tremors, and finally downer, 1-5 days after death.
8. Raccoon pasteurellosis:
(1) acute type: Most patients sudden death raccoon, common raccoon, Aberdeen, born the same year, early disease depression, body temperature of 40 ℃ or more, decreased appetite, and soon waste must, nasal dryness, breathing difficulties, like cold water, transport step is not flexible, often has spastic convulsions and death, the course is generally 1-3 days.
(2) Chronic type: the same symptoms and acute type, but longer duration, the final result of paralysis, failure and death.
9. Pasteurella disease of mink:
(1) the most acute form: often no symptoms and sudden death.
(2) acute type: common, the performance increase in body temperature of 41 ℃, nasal dryness, decreased appetite, early disease, post-waste must, very few activities or does not move, breathing difficulties, and sometimes paralysis of limbs, mostly in a coma or convulsions of death, duration 1-5 days.
10. Silver Black Fox pasteurellosis:
More sudden on_set_, manifested as decreased appetite, and even waste must, shortness of breath, depression, hair disheveled, often Woyu cage side, conjunctival flushing, sticky mucus, the body temperature of 40-42 ℃, and nasal discharge plasma of nasal fluid. Diarrhea in early disease, post-ejection dung. Course of several hours to 2 days.
Five. Pathological changes
Since the body resistance, bacterial virulence and the number of different invasive bacteria, and various animal different susceptibility of the bacteria, so there are differences in pathological changes.
1. Birds:
The most acute form, no special disease chickens died, and sometimes can only see a little bleeding epicardium.
More characteristic of acute cases of disease, chickens in the peritoneum, subcutaneous tissue and abdominal fat common dot bleeding. Pericardial thickening, pericardial volume of the inner product of a number of opaque light yellow liquid, some liquid containing cellulose floc, the epicardium, especially bleeding heart fat crown. Lung congestion, or bleeding. With characteristic liver lesions, liver slightly swollen, qualitative change in crisp, brown or yellow brown. There are many gray surface spread of liver, large necrosis of needle point. Generally not seen significant changes in the spleen, or slightly swollen, softer texture. Significant muscle bleeding, bowel, especially the duodenum was catarrhal and hemorrhagic enteritis, intestinal contents contain blood.
Chronic form due to abuse differ among organs. When respiratory symptoms in time to see how the amount of nasal cavity and paranasal sinuses sticky secretions, some patients see the lung hardware change. Limited to cases of arthritis and tenosynovitis, joint swelling deformation of the main see, there are inflammatory exudate and caseous necrosis. Meat beard cock enlargement, there are cheese-like exudation, hen's ovary was bleeding, and sometimes deformed follicles, it seems like half-cooked.
Pathological changes of ducks and chickens are similar, the ducks died of avian cholera is filled with transparent orange pericardial exudate, the pericardium, the heart has the highest fat, bleeding spots. Showed multiple pulmonary pneumonia, emphysema and bleeding between. Nasal mucous membrane congestion or hemorrhage. Slightly enlarged liver, showing a white needle-like bleeding and necrosis of points. To the small intestine and large intestine mucosa preceding the most severe congestion and hemorrhage; small intestine and cecum after the section of light. Ducklings as polyarthritis, primarily the articular surface roughness can be seen, attached to a yellow cheese-like substance or red granulation tissue. Thickening of the joint capsule, containing red slurry or sallow, turbid viscous liquid. Occurrence of liver steatosis and focal necrosis.
2. Pig:
The most acute: acute inflammation of the throat mucous, serous infiltration of the surrounding tissue. Bleeding swollen lymph nodes. Acute pulmonary edema, kidney and bladder may be bleeding. In addition to bleeding spots skin, the mucous membrane bleeding and sometimes there are small points. Spleen not enlarged.
Acute type: mainly pleural pneumonia, lung lesions of the pneumonia, bleeding spots, edema, emphysema and liver changes the red zone, or a fiber-like adhesive material, often associated with pleural adhesions. Bronchial lymph nodes, gastrointestinal tract inflammation catarrhal inflammation or bleeding.
See multiple chronic type of lung necrosis. Pleural and pericardial adhesion cellulose floc. The time of diagnosis, can take pigs liver, spleen and lymph nodes as smear staining and found that the small bipolar staining bacilli, with symptoms and pathological diagnosis and medical history can be made.
3. Cattle:
Sepsis is generally lost cattle blood changes;
Edema seen in cases of head, neck and throat swelling. Acute lymphadenitis and liver, kidney, heart and other solid organ degeneration, splenomegaly is rare.
Pneumonic cellulose mainly pneumonia and pleurisy, lung section marble-like change.
4. Sheep:
Subcutaneous infiltration of liquid and small bleeding points. Mucosa, serosa and visceral bleeding, pleural effusion, pulmonary congestion, a small bleeding spots and liver changes. Other organ edema, hyperemia, small bleeding points between, but not enlarged spleen, inflammation of gastrointestinal bleeding; the bodies of a longer duration of weight loss, subcutaneous colloid infiltration, a common cellulose pleurisy, pneumonia and pericarditis, liver has necrosis.
5. Rabbit:
Rabbits died from rhinitis patients with nasal-type plot, or how the amount of viscous purulent secretions within the sinuses and paranasal sinus discharge, sinus lining mucosal swelling;
Cellulose-based usually presents with acute pneumonia, pneumonia and pleurisy change;
In addition to general septicemia sepsis-type changes, the common changes in rhinitis and pneumonia, liver degeneration, and necrosis of the small number of points;
Otitis media type red tympanic membrane and tympanic wall, sometimes tympanic rupture, purulent exudate logistics into the ear canal, severe purulent meningitis when lesions.
6. Ma:
Ma Pasteurellosis mainly in the pleura, pericardium and intestinal serosa, and fat has a lot of bleeding hearts crown point, apex leaf common bleeding, liver and spleen often no obvious change; the dead donkey necrosis of the liver has a large number of points, spleen edge a little bit like bleeding, bleeding gastric pylorus spot, the bladder mucosa diffuse spotting.
7. Deer:
A large number of dead deer in the subcutaneous tissue and a serous infiltration of scattered bleeding points, so the stomach and intestinal bleeding inflammation, especially in the duodenum and cecum bleeding obvious changes of pneumonia, lymph congestion, edema and hemorrhage.
8. Raccoon:
Raccoon dog died of acute cases, good nutrition, and rigor mortis is not complete, conjunctival anemia, oral mucosa bleeding spots, bleeding heart crown point, endocardial papillary muscle at the base with small bleeding spots, emphysema; surface bleeding , intestinal lymph nodes, cut, juicy, easy to fall off and have the stomach mucous membrane bleeding, small intestinal bleeding, colon showed catarrhal enteritis, spleen and blood, but not swelling, enlargement of the liver necrosis gray surface of the bladder , mucous membrane bleeding; chronic cases of malnutrition, body weight loss, anemia, all solid organ serous, mucous membrane bleeding, stomach wall thinning, limited bleeding, secondary to pneumonia, the apex leaves, leaf heart inflammation changes.
9. Mink:
In real dead mink organs and mucous membranes, serous haemorrhage as the main feature, body surface lymph nodes, mesenteric lymph nodes and small bleeding points.
10. Silver foxes:
Silver foxes dead bodies of good nutrition. Subcutaneous tissue, mucous membrane, serous membrane on the tip as large as millet are major bleeding. Nasal, tracheal mucus, and there is a lot of bleeding, lung dark red, diffused surface bleeding of varying sizes, cut juicy, hilar lymph nodes. Epicardium and pericardium are the tip bleeding point. Enlargement of the liver, the surface of a large number of white blood spots and necrosis. Spleen is also enlarged, was cherry red. Kidney scattered bleeding points. Wide range of gastrointestinal mucosal bleeding.
VI. Diagnosis
1. Microbiological examination:
(1) diseased collection: Take the organization of livestock and poultry disease, liver, lung, spleen and other body fluids, secretions and exudates of local lesions.
(2) microscopic examination: the original patient material for Gram stain smear, microscopic examination, should be gram negative. With India ink and other dyes, the capsule can be seen clearly.
(3) culture: blood agar and were inoculated MacConkey agar, 37 ℃ cultured 24h, observing the growth of bacteria, colony characteristics, hemolysis, and staining.
(4) Biochemical test: 48h Pasteurella multocida in the biodegradable glucose, fructose, single toffee, sucrose and mannose, acid no gas. Generally do not ferment lactose, rhamnose, inulin, salicin and inositol. Can produce hydrogen sulfide, indole can be formed, mr and vp test were negative. Catalase and oxidase tests were positive. Hemolytic Pasteurella does not produce indole, acid production can ferment lactose. To ferment glucose, glycogen, inositol, maltose, starch; not fermented alcohol side marigold, inulin, and Erythritol.
2. Animal testing: Test animals used mice and rabbits. Autopsy immediately after the death of experimental animals, and take blood and parenchymal organs separation and smear staining, see a large number of poles stain bacteria can be confirmed.
3. Serotype or biotype identification: available passive hemagglutination test, agglutination test for identification of Pasteurella multocida capsular serogroup and serotype. Measured by indirect hemagglutination test of hemolytic Pasteurella serotypes, biochemical identification of bacteria according to the biological type.
VII. Prevention:
1. Birds:
Flocks of feeding and management to enhance, usually strictly farms veterinary health and disease prevention measures to be taken as the unit Building homes in all out of keeping the whole system to prevent the occurrence of this disease is entirely possible. General farms, the disease has never occurred without vaccination.
Treatment of disease in chickens should take immediate measures to local conditions should be _select_ed through an effective drug susceptibility testing all group administration. Sulfonamides, chloramphenicol, erythromycin, gentamicin, ciprofloxacin, enrofloxacin, olaquindox have a good effect. In the course of treatment, dosage should be adequate, and reasonable course of treatment, significantly reduced when the chickens died, and then continue 2 ~ 3d dosage to consolidate the curative effect to prevent relapse.
Often prone areas or on farms, drug treatment gradually reduced, the disease is difficult to be effectively controlled, can consider the application of vaccines for prevention, because of immunity is short, the control effect is not very satisfactory. In conditions where bacteria can be isolated in the field, the tests are to produce their own vaccine, chickens were injected on a regular basis, proven by 1 to 2 years of immunity, the disease can be effectively controlled. There are good domestic fowl cholera vaccine propolis, safe and reliable, can be preserved for two years at 0 ℃, easy-to-injection, does not affect egg production, non-toxic side effects, which can effectively control the disease.
2. Pig:
3. Cattle:
(1) isolated from infected cattle breeding.
(2) drug treatment ① 2% of ofloxacin injection per kg body weight 3 to 5 mg intramuscular injection, intramuscular injection of gentamicin compound 2 times a day, 3 days for a course of treatment. ② Ciprofloxacin powder drink the whole group. ③ 10% lime water disinfection pens, 2 or 3 times a day. ④ injection of bovine vaccine out of defeat.
4. Sheep:
(1) improve environmental sanitation pens, regular use of 2% to 4% caustic soda were disinfected.
(2) Note changes in the environment, such as temperature mutation, transport, feed, change and other drug prevention to be used.
(3) in the treatment and prevention available antibiotics and sulfa drugs.
5. Rabbit:
Rabbit farm to be bred and self-support. The introduction of rabbits to strict inspections and quarantine month for bacteriological examination, healthy rabbits were allowed to enter the field. To strengthen management, rabbit farm livestock access is prohibited to prevent the source of infection. After the on_set_ of isolation, blockade of the term is generally 20 days. Sick rabbit hunting. Runny nose, cough, the disease should be promptly treated in isolation of rabbit, rabbit chronic diseases to be eliminated. Tushe with 10% - 20% milk of lime or 2% - 3% caustic soda solution regularly disinfected.
Available when the prevention of rabbit pasteurellosis vaccine aluminum hydroxide or poultry infected rabbit Pasteurella multocida vaccine injection, or RHDV, rabbit bivalent Pasteurella vaccine immunization. Twice a year.
Intramuscular streptomycin treatment available for every kilogram of body weight 2 - 4 million units, 1 to 2 times, once every 3 - 5 days; if with penicillin (measured the same) combination, the better. Sulfadiazine tablets per kilogram of body weight 0.05 - 0.2g, with the same amount of baking soda tablets taken twice daily. Chloramphenicol injection per kg body weight 60 - 100mg, tablets per rabbit 0.1 - 0.15g, twice daily, with good results. Tetracycline, kalamycin, sulfonamides are effective synergist.
Acute cases, subcutaneous injection of polyvalent serum against a failure, per kilogram of body weight of about 60ml, 1 to 2 times a significant effect. Obvious symptoms of respiratory disease in rabbits, chloramphenicol and other antibiotics can be used intranasally, every 3 - 4 drops, 1 to 2 times a significant effect.
6. Other:
Found that the disease should be isolated immediately, emergency immunization, drug prevention and treatment, disinfection and other measures; will have disease or animal body height all the isolation, vaccination of healthy animals immediately, or drug prevention, to conduct a thorough disinfection of the environment pollution .
Offal and meat carcasses significant lesions for industrial use or destroyed; no lesion or lesions are mild and the meat cut off the corpse, appeared after heat treatment; blood for industrial use, fur, feathers, appeared after disinfection.
Input from outside the quarantine of live animals found pasteurellosis, returned or slaughtered destroyed, and the other in animal quarantine release to the designated place. Enter the quarantine of animal products for pesticides when pathogen Pasteurella, returned or destroyed. |