Shikimic acid [Chinese name]: shikimic acid [English name]: shikimic acid [Plant Origin]: shikimic acid present in the magnolia evergreen shrub Mangcao illicium lanceolatum ac smith in the dry fruit of star anise. Mangcao plants high 3m ~ 8m, leathery, 1 to 2 axillary; top with long, curved tip; seeds light brown, shiny. Flowering in May, fruit from September to October. Globally, 90% of the octagonal produced in China, mainly in Fujian, Guangdong, Guangxi, Yunnan and Guizhou provinces loose soil of the mountain. In addition to plants, shikimic acid is also widely present in microorganisms, can also be extracted through the fermentation of shikimic acid. [Molecular formula and molecular weight]: c7h10o5; 174.15 [Properties]: white fine powder, easily soluble in water, solubility in water 18g/100ml insoluble in chloroform, benzene and petroleum ether. Melting point of 185 ℃ ~ 191 ℃, rotation -180 °, smell bitter. [Pharmacology]: shikimic acid by affecting arachidonic acid metabolism, inhibition of platelet aggregation, inhibition of vein thrombosis and cerebral thrombosis, shikimic acid has anti-inflammatory and analgesic effects, shikimic acid can be used as antiviral and anticancer pharmaceutical intermediates. [Add] Huang Jianmei Beijing University of Chinese Medicine is the study of star anise plants, associate professor of experts, in the face of journalists, Huang Jianmei said, in fact, very common shikimic acid is the same thing, if it is bird flu, if it was released against avian Roche influenza-specific drug "Tamiflu" extracted from star anise in the shikimic acid, may never be anyone concerned about the shikimic acid, and no one will realize that the original star anise is a traditional Chinese medicine. Huang Jianmei confirmed, star anise contains a toxin called Mangcao composition, for the role of human nervous with convulsions. But she said it could not answer Mangcao toxins and Japan, "Duffy" case is about side effects. "Eight? Home burn boiled eggs ah" Octagonal, of Xin Wen, Qi and relieve pain, warm in the cold, has been an indispensable condiment. Shanghai Yueyang Hospital of practitioners more than 40 years, said Dr Yong-sen, star anise can indeed be used as medicine, used in Chinese medicine treatment of gastrointestinal discomfort, vomiting and diarrhea. However, Dr Lu said that he employed more than 40 years, never seen a recipe out there to open the herb star anise. Huang Jianmei also said that star anise is indeed very little medicine, especially the cultivated anise, major role in for seasoning. Some wild anise, or Illicium plants will be used in the civil anti-rheumatic, but this use was not found in Pharmacopeia. "Prescriptions in the hospital will be on the octagonal opening joke blindly. Octagonal open to me? Let me go back and burn boiled eggs ah. "Dr Lu said jokingly. Huang Jianmei, said first main component of anise essential oil, volatile oil that is this issue very fragrant anise flavor. Followed by the flavonoids, the last is very amazing that fired shikimic acid. Guangxi producing shikimic acid from star anise in about 12%. Three-drug, star anise is no exception Huang Jianmei confirmed, star anise contains a toxin called Mangcao composition, for the role of human nervous with convulsions. But she said it could not answer Mangcao toxins and Japan, "Duffy" case is about side effects. Huang Jianmei said that although the names of shikimic acid and Mangcao toxins similar, in fact, are two completely different things. Shikimic acid (shikimicacid) is an organic acid, and Mangcao toxin (anisatin) is a sesquiterpenoid substances. Although shikimic acid and methanol Mangcao toxins can be extracted from star anise in together, but separation of the two substances is not difficult. Octagonal in Mangcao planted very low levels of toxins, but the wild plants of anise and star anise with a high Mangcao toxins. But this is only illustrative octagonal contains toxins cause neurological seizures, and shikimic acid did not have any relationship. And star anise as "God" a lot of plants In addition to plants, shikimic acid is also widely present in microorganisms, can also be extracted through the fermentation of shikimic acid. Roche also admitted that "Tamiflu" as used in a part of shikimic acid from Escherichia coli fermentation. "Tamiflu" in the anti-viral components, through further refining of the conversion of shikimic acid derivatives generated, nor is the presence of shikimic acid resistant avian influenza virus. "Star Anise contains a major anti-virus component of shikimic acid," Such a reference is certainly wrong. If the shikimic acid resistant to direct effects on bird flu, then there are numerous nature of plants resistant to avian flu, such as pine needles, also contains a lot of isopropylidene shikimic acid. To blindly buy star anise, in fact, pick pine needles into the light, the role of about the same. For Roche had previously announced Preparation "Tamiflu," the process, in fact, most of shikimic acid from star anise extract process. Huang Jianmei said extracting shikimic acid is a very easy thing. Slightly basic conditions in the laboratory can be completed. Shikimic acid is by no means the mystery of Roche's technology focus is on the further conversion of shikimic acid. The general purpose of shikimic acid Huang Jianmei said that before the general thoroughfare shikimic acid is used as a chemical raw material, used to convert to other chemicals or chemical agents. Octagonal every year, many Chinese exports to Europe, especially Germany, the majority. But mainly extracted from star anise essential oil production of food additives. Most drugs derived from shikimic acid in the experimental stage, but such experiments report very much. "Tamiflu" should be regarded as a successful example of the earlier experiments, made in the last century 90's shikimic acid derivatives as antiviral drugs. Second, the role of the cardiovascular system, Beijing University of Chinese Medicine Sun Jianning of shikimic acid and its derivatives such as three-acetyl and isopropylidene shikimic acid shikimic acid on the cardiovascular system, and found that all three compounds with anti- thrombosis and inhibition of platelet aggregation, and their mechanism were studied.
Translated by Google
[Properties]:
Fine white powder, soluble in water, solubility in water 18g/100ml, insoluble in chloroform, benzene and petroleum ether. Melting point of 185 ℃ ~ 191 ℃, rotation -180 °, smell bitter.
Translated by Google
[Pharmacology]:
Shikimic acid by affecting arachidonic acid metabolism, inhibition of platelet aggregation, inhibition of vein thrombosis and cerebral thrombosis, shikimic acid has anti-inflammatory and analgesic effects, shikimic acid can be used as antiviral and anticancer drug intermediates.
Translated by Google
[Add]
Huang Jianmei Beijing University of Chinese Medicine is the study of star anise plants, associate professor of experts, in the face of journalists, Huang Jianmei said, in fact, very common shikimic acid is the same thing, if it is bird flu, if it is Roche's anti-bird flu vaccine or treatment announced "Duffy" extracted from star anise in the shikimic acid, may never be anyone concerned about the shikimic acid, and no one will realize that the original star anise is a traditional Chinese medicine. "Eight? Home burn boiled eggs ah" Octagonal, of Xin Wen, Qi and relieve pain, warm in the cold, has been an indispensable condiment. Shanghai Yueyang Hospital of practitioners more than 40 years, said Dr Yong-sen, star anise can indeed be used as medicine, used in Chinese medicine treatment of gastrointestinal discomfort, vomiting and diarrhea. However, Dr Lu said that he employed more than 40 years, never seen a recipe out there to open the herb star anise. Huang Jianmei also said that star anise is indeed very little medicine, especially the cultivated anise, major role in for seasoning. Some wild anise, or Illicium plants will be used in the civil anti-rheumatic, but this use was not found in Pharmacopeia. "Prescriptions in the hospital will be on the octagonal opening joke blindly. Octagonal open to me? Let me go back and burn boiled eggs ah. "Dr Lu said jokingly. Huang Jianmei, said first main component of anise essential oil, volatile oil that is this issue very fragrant anise flavor. Followed by the flavonoids, the last is very amazing that fired shikimic acid. Guangxi producing shikimic acid from star anise in about 12%. Three-drug, star anise is no exception. Huang Jianmei confirmed, star anise contains a toxin called Mangcao composition, for the role of human nervous with convulsions. But she said it could not answer Mangcao toxins and Japan, "Duffy" case is about side effects. Huang Jianmei said that although the names of shikimic acid and Mangcao toxins similar, in fact, are two completely different things. Shikimic acid (Shikimicacid) is an organic acid, and Mangcao toxin (Anisatin) is a sesquiterpenoid substances. Although shikimic acid and methanol Mangcao toxins can be extracted from star anise in together, but separation of the two substances is not difficult. Octagonal in Mangcao planted very low levels of toxins, but the wild plants of anise and star anise with a high Mangcao toxins. But this is only illustrative octagonal contains toxins cause neurological seizures, and shikimic acid did not have any relationship. And star anise as "God" a lot of plants In addition to plants, shikimic acid is also widely present in microorganisms, can also be extracted through the fermentation of shikimic acid. Roche also admitted that "Tamiflu" as used in a part of shikimic acid from Escherichia coli fermentation. "Tamiflu" in the anti-viral components, through further refining of the conversion of shikimic acid derivatives generated, nor is the presence of shikimic acid resistant avian influenza virus. "Star Anise contains a major anti-virus component of shikimic acid," Such a reference is certainly wrong. If the shikimic acid resistant to direct effects on bird flu, then there are numerous nature of plants resistant to avian flu, such as pine needles, also contains a lot of isopropylidene shikimic acid. To blindly buy star anise, in fact, pick pine needles into the light, the role of about the same. For Roche had previously announced Preparation "Tamiflu," the process, in fact, most of shikimic acid from star anise extract process. Huang Jianmei said extracting shikimic acid is a very easy thing. Slightly basic conditions in the laboratory can be completed. Shikimic acid is by no means the mystery of Roche's technology focus is on the further conversion of shikimic acid. The general purpose of shikimic acid Huang Jianmei said that before the general thoroughfare shikimic acid is used as a chemical raw material, used to convert to other chemicals or chemical agents. Octagonal every year, many Chinese exports to Europe, especially Germany, the majority. But mainly extracted from star anise essential oil production of food additives. Most drugs derived from shikimic acid in the experimental stage, but such experiments report very much. "Tamiflu" should be regarded as a successful example of the earlier experiments, made in the last century 90's shikimic acid derivatives as antiviral drugs. Second, the role of the cardiovascular system, Beijing University of Chinese Medicine Sun Jianning of shikimic acid and its derivatives such as three-acetyl and isopropylidene shikimic acid shikimic acid on the cardiovascular system, and found that all three compounds with anti- thrombosis and inhibition of platelet aggregation, and their mechanism were studied.