Grass name. Also known as white stems, ground bones. Bitter root can be used as medicine
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No. 2
Ting Li flavescens hook keep emerging grass. - Ming Liu Ji "Bitter fast mind"
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Plant name
Plant names. Deciduous sub-shrub, pinnate, leaflets ovate oblong, racemes, corolla yellow. Root medicine, the role of a heat detoxification. "Shen Nong Ben Cao Jing" Volume II: "flavescens, taste the bitter cold, the main confidants knot gas Zhengjia accumulation, jaundice, drowning more than Lek, by water, in addition to carbuncle swollen, fill in eyesight, only tears."
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Basic information
【Source】 This product legumes flavescens sophora flavescens ait.'s Dried root. 【Alias】: bone pain ("outline"), Chuan Shen ("Guizhou Folk Recipe Collection"), phoenix claws ("Guangxi veterinary medicine plant"), cattle Participation ("Hunan Drug Chi"). Flavescens, also known as: bitter knowledge, water locust (the "Classic"), to Huai, dodder Huai Huai arrogant, white stems, Tiger Ma, Cen stems, Lu Bai, Ling Lang ("Do not record"), wild locust ("outline"), locust hill sub, white calyx. Bitter to taste name, reference to fame, hence the name Sophora. 【Name】 prescription: flavescens, fried flavescens, Sophora charcoal. Students write prescriptions that Sophora flavescens. To impurities in the original herbs and Lo head and fibrous roots, washed and dried, sliced medicine are. Sophora flavescens fried slices to stir-fry until yellowish medicine by using bran. Sophora flavescens charcoal outside the charred pieces fry with high heat, brown inside, storage of, and then medicine person. 【Indication】 heat dampness, insecticide, diuretic. For hot dysentery, blood in the stool, jaundice urinate, Chibai vaginal discharge, vaginal swelling Yin itching, eczema, eczema, skin itching, scabies, leprosy; external treatment trichomonas vaginitis. 【Application】 1. For the hot and humid diarrhea, jaundice, Chibai vaginal discharge, genital itching embolism. Often associated with cork, gentian, etc. combined. 2. For the whole body wind itching, scabies stubborn psoriasis, leprosy embolism. Often associated with TPG, to yellow, white leather equated with moss; for leprosy, often equated with children with large maple. Dosage decoction, 4.5 ~ 9g. External use, Jiantang wash the affected area. 【Note】 This product is bitter cold Shang Wei, Shangyin, spleen Deficiency and Yin-chun injured caution. Anti Veratrum.
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Original plant
Flavescens is a perennial herb or shrub, 1.5-3 m high. Root cylindrical, up to 1 m, the skin yellow. Odd pinnate, 20 to 25 cm long; leaflets l5-36, lanceolate to linear-lanceolate, rarely elliptic, 3-4 cm long, 1.2-2 cm wide, apex acuminate, base rounded, appressed pilose on the back. Raceme top students, with sparsely pubescent or nearly glabrous; Corolla pale yellow, flag flap spoon-shaped, petals without ears. Pod 5-8 cm long, seed overflow between the micro-contraction was not revealed in the string of beads, sparsely pubescent, with seeds 1-5 pieces. Fruit 6-9 month period. Around the wild, born in the foothills of sunny slopes and grass, country, street, Gully side; North and South provinces are distributed. Root for medicinal, there is heat and detoxifying, anti-bacterial anti-inflammatory, heat treatment, jaundice, dysentery, enteritis, skin itching embolism; stem bark fiber can be woven sacks.
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Textual Research
Flavescens only contained in the "Shen Nong's Herbal Classic", as in the product. "Materia Medica variorum" _set_: "Today a short cut, everywhere. Mimicking locust tree leaves, so there Huai name. Flowers yellow, the Son as the pod, the root to the bitter taste of evil." "The sketches by" _set_: "to his roots yellow, long-Five Seven 寸许, the thickness of two fingers. three to five stems, and Health, mu Middle School has four feet. chopped green leaf, mimicking Salvinia, so there is water Huai name. Chunsheng winter tune. The yellow and white flowers in July solid such as string bean. "" Compendium of Materia Medica, "said:" bitter to taste name, reference to fame. "this above all with the consistent form with matrine. "The sketches by" Sophora map with four, in addition to Xijing flavescens, Sophora Shao state, the other two images (as the Germans and Qinzhou Sophora flavescens) are also used in modern form similar to matrine.
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Identification of raw medicinal herbs
Dried roots were cylindrical, 10 to 30 cm in diameter and 1 to 2.4 cm. Vertical surface was wrinkled, and slightly prominent lenticels apparent anti-roll and lateral extension. Cork thin, brown or gray brown, curly most broken out, easy to peel off and smooth on the skin appear yellow. Quality hard and difficult to break, fracture surface rough fibrous. Yellow-white cross-section to form a layer of clear. Air pungent, very bitter taste. Flavescens piece oblique slices, shapes and sizes, round or oblong oblique, long 2 to 5 cm, width 1 to 1.5 cm, thickness 2 to 5 mm. Quality hard, yellowish white cut surface, there is ring ring, xylem for the radiation pattern. To tidy, yellow and white color, bitter taste are preferred. Are produced around the country, Shanxi, Hubei, Henan, Hebei yield larger. Microscopic identification: root cross-section: cork layer of cork cells in multiple columns. Cortex narrow. Phloem scattered with fiber bundles, fiber bundles around the cell containing calcium oxalate crystals to form a crystal fiber, crystal cell wall of wood of uniform thickness; ray wide and clear, almost to the formation of cork not a ring. Xylem radially arranged; wood fiber for crystal fiber. Powder: yellow. ① starch granules round or oblong, diameter 4-22μm, Umbilical point crack-like, laminated looming large grain; complex composed of grain particles from the 2-12 minutes. ② fiber slender, straight or slightly curved, diameter 11-27μm, the wall is very thick, non-wood based, colporate obvious, cell-line. Fibers around the cells with calcium oxalate crystals to form a crystal fiber, with no increase in crystal cell walls of wood of uniform thickness; calcium oxalate crystal class of two cone-shaped, diamond or surface shape. ③ bordered pits vessel diameter 27-126μm, closely arranged bordered pits, and some number of lines connected linear orifice. Also netted catheter. ④ round or class of thin-walled rectangular cells, walls thicker, and some showed uneven Pente-like, non-wood based, large and small pits, some integrated field pits, and some cell-crystal with a small needle. ⑤ View class polygonal cork cells, anticlinal walls are shaped pits were intermittent, irregular surface of small cracks. Another occasional stone cells.
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Chinese Medicines
Root contains a variety of alkaloids (1% -2.5%) to d-matrine (d-matrine) and d-oxymatrine (d-oxyma-trine) the main content of the ratio between the two, due to origin Different vary greatly, Northeast China produced more content oxymatrine. Also contain trace amounts of d-matrine alcohol base (d-sophoranole), l-stinky bean base (l-anagyrine), l-methyl-cytisine (l-methylcytisine), l-wild indigo leaf base (l-baptifoline) , l-sophocarpine (l-sophocarpine), n-oxysophocarpine (n-oxysophocarpine), l-ethyl-Huai Ming alkali (l-ethylsophoramine), sophoridine (sophoridine), tetrandrine and so on. Flavonoids are flavescens (kurarinone), iso matrine (isokurarinone), to a matrine (norkurarinoe), sub-matrine (kuraridin), matrine alcohol hormone (kutstinol), sub-prime flavescens alcohol (kuraridinol ), the new prime flavescens alcohol (neokurarinol), matrine alcohol to a hormone (norkurarinol), to a dehydration Epimedium hormone (noranhydroicaritin), dehydration Epimedium different factors (isoanhydroicaritin), hop elements (xanthohumol), different hop elements (isoxanthohumol) and clover beans Korea Sophoricoside (trifolirhizin, l-maackiain-β-d-glucoside) and so on.
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Chemical identification of traditional Chinese medicine
(1) cross-section of this product, add a few drops of sodium hydroxide test solution, the Ministry of the cork was orange-red, long home does not disappear. (2) to take this product powder 0.5g, add methanol 10ml, heat reflux 10min, filtered, the filtrate obtained 1ml, home test tube, add 3-4 drops of magnesium and hydrochloric acid a small amount of heating, which was red. In another filtrate 5μl, points on the filter paper, sprayed with 5% ethanol solution of aluminum chloride, drying, home UV light (254nm) was observed, which was yellow-green fluorescence. (Check the flavonoid) (3) to take this product meal 1g, containing 0.5% HCl plus ethanol 20ml, reflux 1h, filtered, the filtrate add ammonia solution to neutral, evaporated and the residue plus 1% hydrochloric acid solution Dissolve 10ml, filtration, the filtrate obtained three split tubes, one tube of bismuth potassium iodine test solution to produce red-brown precipitate; a test solution of potassium iodine of mercury to produce yellow-white precipitate; another iodine plus potassium iodide test solution tube to produce brown precipitate. (Check the alkaloids) (4) TLC: to the product powder 0.5g, 25ml chloroform and strong ammonia solution 0.3ml, overnight, filtration, the filtrate evaporated and the residue added to 0.5ml of chloroform dissolved, as the test fluid. In another oxymatrine and sophoridine, add ethanol into each containing 0.2mg per ml of mixed solution, as the reference solution. Draw the solution of 4μl, respectively, at the same point with 2% sodium hydroxide solution g of silica gel thin-layer plate prepared with toluene - ethyl acetate - methanol - water (2:4:2:1) started 8cm, remove, dry, and then with toluene - acetone - ethanol - concentrated ammonia solution (20:20:3:1) to start with the first show from the same removed, dried, and then click sprayed with test solution and nitrite bismuth potassium iodide sodium ethanol test solution. Test products for chromatography, chromatography with reference substance corresponding position, was the same two brown spots.
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No. 10
【Chinese Name】: Sophora 【Type】: Sophora root class ("The Classic") Synonyms】 【bone pain ("outline"), Chuan Shen ("Guizhou Folk Recipe Collection"), Phoenix claws ("Guangxi veterinary medicine plant"), cattle Participation ("Hunan Drug Chi"). 【Source】 for the bean root of Sophora species. 【Form】 Sophora plants, also known as: water locust (the "Classic"), to Huai, dodder Huai Huai arrogant, white stems, Tiger Ma, Cen stems, Lu Bai, Ling Lang ("Do not record"), wild Cassia ("outline"), locust hill sub, white calyx. Born in the hillside grassland, plain, roadside, sandy land and red soil in sunny place. Jieyou distributed all over the country. The seeds of this plant (Sophora real) also for medicinal, and the other details of special articles. 【Collection】 spring and autumn harvest, autumn and mining is preferred. Excavated root, remove the root head, fibrous roots, washed sand, dry. Dried slices of fresh root, known as Sophora film. Dry root herbs】 【was cylindrical, 10 to 30 cm in diameter and 1 to 2.4 cm. Vertical surface was wrinkled, and slightly prominent lenticels apparent anti-roll and lateral extension. Cork thin, brown or gray brown, curly most broken out, easy to peel off and smooth on the skin appear yellow. Quality hard and difficult to break, fracture surface rough fibrous. Yellow-white cross-section to form a layer of clear. Air pungent, very bitter taste. Flavescens piece oblique slices, shapes and sizes, round or oblong oblique, long 2 to 5 cm, width 1 to 1.5 cm, thickness 2 to 5 mm. Quality hard, yellowish white cut surface, there is ring ring, xylem for the radiation pattern. To tidy, yellow and white color, bitter taste are preferred. Are produced around the country, Shanxi, Hubei, Henan, Hebei yield larger. Chemical Composition】 【root contains a variety of alkaloids: d-matrine, d-oxymatrine, SJ smell alcohol l-bean base, l-methyl-cytisine, l-wearing pseudo-indigo leaf base and Huai fruit base. Also contains flavonoids: fulvic alcohol, fulvic different alcohols, 3,4 ', 5 - Three hydroxyl -7-- methoxy -8-- prenyl flavonoids, 8 - prenyl kaempferol and so on. Stems and leaves contain luteolin -7-- glucoside. Pharmacological effects】 ① diuresis Decoction of matrine and matrine contained a rabbit orally or by injection, can be produced diuresis, increased urine excretion of the former that is more salt. But the experiment the number of rabbits used in the less control they did not describe the situation of drinking water, which suggested that further research is needed. ② the role of anti-pathogen Decoction in vitro, high concentration (1:100) on the inhibition of Mycobacterium tuberculosis. Decoction (8%), flooding agent (1:3) in vitro of certain common skin fungi have different degrees of inhibition. There are anti-alcohol extract of Trichomonas in vitro effect, weaker than berberine, which is similar with Cnidium. ③ other roles Matrine injection in rabbits and found that central nervous system paralysis, and spasm, and finally the respiratory arrest and died. Injected into frogs, the beginning was exciting, after the paralysis, breathing becomes slow and irregular, the last spasm, resulting in respiratory arrest and died; the on_set_ of seizures, the causes of fear, Department of hyperthyroidism in spinal cord reflex. The minimum lethal dose in rabbits was 0.4 g / kg. 【】 Sorting net processing impurities, remove residual stems, wash the soil, water soaking, remove, run through, sliced, dried in the sun. "Treatise on Thunder Gun": "Where to flavescens, the first concentration required Gan juice soaked glutinous rice one night, on a bad smell fishy floating in the water, and be heavily panned, the steaming, from Pat to the application out, dried thin file used. " 】 【Taste bitter, cold. ① "The Classic": "bitter, cold." ② "Do not Catalog": "non-toxic." ③ "new Materia Medica": "great bitterness, Big Chill." Meridian】 【hepatic, kidney, large intestine, small intestine. ① Zhang elements: "Shao Yin Kidney Meridian." ② "concocted herbal solutions Thunder": "stomach, large intestine, liver and kidney after four." ③ "New Materia Medica": "into the heart, lung, kidney, large intestine." 【Indications】 function of heat, dampness, kills. Governance Noxious Heat dysentery, intestinal wind of blood, jaundice, Chibai vaginal discharge, pneumonia, malnutrition product, acute tonsillitis, anal fistula, prolapse, pruritus, scabies skin disease malignant sore, sore wet vaginal itching, M. scrofulaceum, burns. Trichomonas vaginitis foreign rule. ① "The Classic": "main confidant Results gas, Zheng Jia accumulation, jaundice, drowning more than Lek, by water, in addition to boils, fill in the eyesight only tears." ② "Do not Catalog": "Liver courage, On the five internal organs, Dingzhi Yi Jing, Lee Jiuqiao, in addition to V hot intestinal bleach, thirst, sober, yellow urine also, hiding the lower part of treatment and malignant sore, flat Stomach, it is preferable . " ③ Hongjing: "evil drink Jiuzi patients suffering from scabies who also served in addition, cover to killing." ④ "medicinal": the "toxic air heat treatment, skin sore muscle irritability, red skin disease eyebrow off, the main exception of the hot drowsiness, governance belly Leng Tong, the evil abdominal pain, in addition to the body, nausea, accumulation of governance trusted." ⑤ "Tang Materia Medica": "Governance tibia acid, evil worm treatment." ⑥ "Japan-China in the Materia Medica": "Malnutrition kill insects. Fried with smoke from the end of the meal drink, cure intestinal wind and heat of blood dysentery." ⑦ "pearl sac": "dewetting." ⑧ "South Yunnan Materia Medica": "cooling, antipyretic drugs, scabies skin disease, sore pus nest. Treatment of skin itching, ringworm sores in blood, naughty white dust, intestinal wind of blood, blood in the stool. Xiaofeng, swelling drug, sputum drug. " ⑨ "new Materia Medica": "dampness, wins heat treatment nocturnal emissions Hua Jing." Usage and Dosage】 Oral: decoction, 1.5 to 3 money; or into pills, powder. External: fried Washed. Taboo】 【spleen Deficiency Jifu. ① "Materia Medica variorum"; "Scrophulariaceae whom so. Evil mother of pearl, Loulu, dodder. Anti Veratrum." ② "Introduction to Medicine": "caution weak stomach." ③ "Ben Cao Jing Shu,:" Jiufu can damage kidney, liver, kidney and no hot Convicted of service. " ①】 【election party rule than Campylobacter: Sophora Chaojiao for the end of Shuiwan Wu Zi Grand. Fifteen pills per serving, rice drink. ("Ren Cun Tong experience side") ② rule anal fistula bleeding, intestinal wind of blood, alcohol poisoning in blood: Sophora (sliced, wine soaked, steamed nine for the degree of drying, fried yellow for the end of the net) a pound, to yellow in two (Jiujin night , steamed, mash.) Add honey for the pills. Second money per clothing, white wine, soup or sent, the date of service twice. ("Great Surgery" Sophora Huang Wan) ③ Valley jaundice treatment, food and complete the first rotation, the heart anger anxiety and depression yellow, by the loss of hunger, Food, Stomach smoked red due to: Sophora two or three, a co-gentian (the end). Wu bovine bile Wanru child. Ginger juice served with five balls, at three. ("Filled the rear elbow") ④ governance Chibai vaginal discharge: Sophora twenty-two, oysters one hundred twenty-five money. For the end to a male pig stomach, three bowls of boiled water, stir mud and pills, Wu Zi Grand. Hundred pills per serving, warm the wine the next. ("Jide Church experience side") ⑤ governance sore lower leakage: Sophora decoction, wash day. ("Ren Fang Zhai directed") ⑥ governance colonic prolapse: flavescens, gall, Chen wall soil decile. Jiantang wash to the end of deposition of wood thieves. ("The medical summary") ⑦ accumulated heat treatment cardiopulmonary, renal toxic air attack in the skin, when the Health and scabies skin disease, itching, when the yellow water, hand, foot rot and high winds or bad, eyebrows off, all the wind illness: Thirty-two flavescens, Nepeta ( to the stem) of two sixteen. For the fine, the water paste as the pill, such as the Indus child large. Thirty pills per serving, tea swallow, or Nepeta soup, the food after the service. ("The Council" Sophora pill) ⑧ septic drain fat sore treatment, septic sore nest, wax pear head, Bianshen wind leprosy, scabies, urticaria, itching, abnormal, insensitive, various wind foot pain, skin broken, scrotum very itchy, and owned by people Yin Yang, wet itch : Sophora pound (the end), Goose (fried sesame oil deposit of) six two. Yellow rice cereal pills, cinnabar for clothing. Send tea, the day the second. Or with the disease as a rub or washing powder, paste. ("Wang Qiuquan family secret" magic treasure Dan) M. scrofulaceum ⑨ Governance: Sophora four ounces, pound at the end, the Health bidentata and Wanru Wu son. Ten pills under warm water after meals, day three. ("Carry emergency preparedness Party") ⑩ treatment of various malignant sore fistula rats: Sophora jin, Lu hive two liang, music jin. Three bucket of water, stains drug two places, to the dregs, millet two liters, wine drinking mature shoot, day three. One plus hedgehog skin, better. ("Filled the rear elbow") Tom iron fire ⑾ pain treatment: Sophora not to how much to fine, adjusted with sesame oil paint. ("Health Treasures" green and white powder) ⑿ sore ear rotation rule (also known as a lunar eclipse sores) since the beginning of the helix or ear, ear lobe at the hair-like swelling on the skin of a yellow rice, surrounded by redness, pus through the top white, itchy, pus, after breaking spillover, the spread of infection, do not be a few days before the ear, dripping pus, sores in children are most vulnerable to this infection: flavescens, Treats all five money, herb, cuttlebone all three money. The research fine, and absorbed. Wrap the affected area with warm water transfer, sooner or later the dressing was changed daily. ("Zhejiang Traditional Chinese Medicine" (6): 27,1958) ⒀ governance Chifeng bleeding: Sophora one or two, dry alum a penny. For the end of days and three arrangements. ("Pu Ji Fang") ⒁ swollen feet ache treatment poisoning heat off those who want to: Sophora cook Jiuzi it. ("Monk Tan Yao _set_ of prescription") 【】 ① clinical treatment of bacillary dysentery I oral law: 50% concentrated decoction, each 20 to 30 ml, at 3 times. Sophora 2 or two, fry 400 ml water 200 ml, the daily 2 pm service, 7 to 10 days for treatment. Also containing 0.5 g of crude drug tablets, each 2 to 4, day for 4 times. Ii injection: 50% of the intramuscular injection 2 to 4 ml, morning and evening 1; intravenous drip 4 to 8 ml, 10% glucose solution 500 ml dilution. Oral decoction is used as adjuvant therapy. Iii enema: 50% decoction 100 ml (plus 0.25% procaine in 10 to 20 ml), a retention enema every night, 7 to 10 days for treatment. Decoction for oral administration and intestinal symptoms were improved after the resumption of obvious pathological cases. Iv Umbilicus method: Sophora powder 8 to 10 grams, transferred into a thick paste with warm water, to make cakes Umbilicus Ministry, covered with oiled paper or gauze bandage fixed. 1 or 2 times a day. According to Shu Baili clinical observation, oral or topical Umbilicus decoction treatment of acute dysentery were more than 85% cure rate. The average number of days in the cure of about 1 week, especially in rapid clinical improvement. Decoction on chronic persistent dysentery, gastrointestinal disorders, in particular type of effect is good. Flavescens Umbilicus, patients with fever being the abdomen, bowel movements increased slightly, exhaust fluent, abdominal pain, then gradually reduce the time and tenesmus, polyuria phenomenon simultaneously. By inference, the umbilical may be drugs to stimulate acupuncture points, through the reflex points, adjust the autonomic nervous system function, promote gastrointestinal blood circulation, enhance leukocyte phagocytosis, which occurred in efficacy. Also has access to its efficacy that there are two aspects: First, the role of the drug itself, and second, the role of umbilical points. ② treatment of acute gastroenteritis Each with 1.5 money decoction, 2 times a day; or syrup (each 100 ml containing crude drug 1 of two), each 10 to 15 ml, served on the 2nd; also be used capsules per 0.5 g dry powder, day for 4 times. General medicine 1 to 2 days to cure. ③ the treatment of acute infectious hepatitis In addition to general liver treatment, with matrine powder 4 grams per day, or made into pills, capsules, 4 times service. Observed in 19 cases, jaundice average of 12.6 days, the shortest of the 3 days; the same time also improved symptoms; hepatomegaly and liver function recovery is also faster. ④ treatment of children with pneumonia ⑤ the treatment of acute tonsillitis, etc. Matrine with 50% of the intramuscular injection, every 2 to 3 ml, 2 times a day, the treatment of acute tonsillitis, acute conjunctivitis, acute mastitis, periodontitis, surgical infections and Boil, pyelonephritis, Acute bronchitis, acute lymphatic go far more than 10 220 cases of acute inflammatory disease, on average, more than 90% efficient, the cure rate of 74% or more. In addition, colitis, cholecystitis, cystitis and other inflammatory also has a certain effect. ⑥ treatment of chronic bronchitis Take flavescens, Platycodon 7:3 tie, joint research to fine, the water pan for the pills. Each time a money, served on the 2nd, 10 Tianyi course of treatment. Treatment interval of 5 days. A total of 498 cases of treatment (all patients over 50 years old), cured two cases, effective in 112 cases, improved in 296 cases, 88 cases ineffective. Effective rate was 82.3%. Side effects: 43 patients had nausea and vomiting, stomach burning sensation and pain, diarrhea, abdominal distension; two cases of nasopharyngeal dry, 1 vertigo. ⑦ Ramsey treatment of giardiasis Oral tablet or syrup made of extracts, a daily adult dose of 30 g crude drug 3 pm service, children reduce for 7 days for one course of treatment. Treatment of 100 patients, 92 were cured. Most of the treatment after 1 to 4, the symptoms disappeared, normal stool, stool examination negative conversion. Some patients were followed up for 3 to 9 months, in addition to an exception, the rest no recurrence. Sophora as decoction with 25% retention enema lines, 100 to 200 ml per adult, 1 day, 5 consecutive times, but also effective, but less than oral better. A sense of nausea after taking a few cases, individual fingers numb, shall not affect the further treatment. ⑧ treatment of human intestinal trichomoniasis Sophora flavescens powder capsule or oral tablets, each adult by 1.2 to 4 g crude drug dose, 3 times a day, children reduce. Generally 10 days for a course of treatment. If results are poor, can also use the decoction of 60 to 50% of Sophora Bank reserves the slide in 100 ml of intestine, day 1. Stool frequency of abdominal pain or significantly higher number of additional symptomatic treatment with Western medicine, there are worms were used along with piperazine citrate drug. According to the results of 54 cases observed, the clinical cure rate was 50%. Cured symptoms and signs for an average of 11.44 days lost, stool examination for an average of 11.67 days was negative. Few cases are dizziness, constipation, appetite loss, nausea and other reactions, were minor, to go away. ⑨ treatment of trichomonas vaginitis Sophora powder with equal amount of 0.6 g and glucose, boric acid powder and dry alum powder and 1 as the amount of line topical treatment. When first used in 1 / 5000 solution of potassium permanganate vaginal lavage, thrown into the powder after drying. 1 day for 3 times for one course. Clinical observation of 176 patients, overall success rate was 71.5%. Symptoms which follow in March, vaginal secretions were not for the trichomoniasis recovered, accounting for 26.1%; track less than 3 months, but symptoms, vaginal secretions were valid without trichomoniasis, 45.4%. Who have cervical erosion is also significantly improved after treatment. A few patients after treatment there was a slight vaginal pain; treatment almost all patients after the review had vaginal epithelium off phenomenon, observed by the tracking no adverse effects on the body. ⑩ treatment of schistosomiasis ascites Sophora every day 6 to 8 grams decoction. Observed in 25 cases, mostly in the 2 days after taking the increased frequency of urination, abdominal circumference decreased, for the purpose of creating the conditions for splenectomy. In addition, it was reported the treatment of filariasis test preparation service flavescens, seems to be insecticidal effect. ② "Materia Medica hundred recorded": "flavescens, cures heart by the fire, and Coptis similar function. But the fire of berberine may go to the heart as much, Sophora like the fire of the small intestine to the multi-Xin Fu, places of berberine smell clean, and smell of Sophora cloud also. by fill in the word is also hard to dry whichever is the meaning of the spleen also. " ③ "Materia Medica of justice": "flavescens, large hard Big Chill, fever drawdown, cleaned up the wet the fire, and its efficacy and Qin, even, gentian are similar, but the pain was even worse flavescens, the dry You Lie, it can heat to kill the worms born, compared with Qin, even the power of strong interest. decoction neighbor is afraid to enter, difficult to cover services not only does an aversion to the bitter taste is also suspected of the Jun Li without fear also. However, the wind bad skin disease virus or it is not eliminated, but that modern people use to wash sores, too due to fear of choking and food waste ears. " 【Storage】 home and dry place.
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Basic information
[Source] "Shen Nong Ben Cao Jing." 【This product is the base of the original legume Leguminosae Sophora dicotyledon Sophora flavescens Ait.'s Dried root. 【Alias】: bone pain ("outline"), Chuan Shen ("Guizhou Folk Recipe Collection"), phoenix claws ("Guangxi veterinary medicine plant"), cattle Participation ("Hunan Drug Chi"). Flavescens, also known as: bitter knowledge, water locust (the "Classic"), to Huai, dodder Huai Huai arrogant, white stems, Tiger Ma, Cen stems, Lu Bai, Ling Lang ("Do not record"), wild locust ("outline"), locust hill sub, white calyx. Bitter to taste name, reference to fame, hence the name Sophora. 【Name】 prescription: flavescens, fried flavescens, Sophora charcoal. Students write prescriptions that Sophora flavescens. To impurities in the original herbs and Lo head and fibrous roots, washed and dried, sliced medicine are. Sophora flavescens fried slices to stir-fry until yellowish medicine by using bran. Sophora flavescens charcoal outside the charred pieces fry with high heat, brown inside, storage of, and then medicine person. [Tropism of taste] bitter cold. The heart, liver, stomach, large intestine, the bladder. 【Indication】 heat dampness, insecticide, diuretic. For hot dysentery, blood in the stool, jaundice urinate, Chibai vaginal discharge, vaginal swelling Yin itching, eczema, eczema, skin itching, scabies, leprosy; external treatment trichomonas vaginitis. 【Application】 1. For the hot and humid diarrhea, jaundice, Chibai vaginal discharge, genital itching embolism. Often associated with cork, gentian, etc. combined. 2. For the whole body wind itching, scabies stubborn psoriasis, leprosy embolism. Often associated with TPG, to yellow, white leather equated with moss; for leprosy, often equated with children with large maple. Dosage decoction, 4.5 ~ 9g. External use, Jiantang wash the affected area. 【Note】 This product is bitter cold Shang Wei, Shangyin, spleen Deficiency and Yin-chun injured caution. Anti Veratrum. Original plant
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Identification of raw medicinal herbs
Dried roots were cylindrical, 10 to 30 cm in diameter and 1 to 2.4 cm. Vertical surface was wrinkled, and slightly prominent lenticels apparent anti-roll and lateral extension. Cork thin, brown or gray brown, curly most broken out, easy to peel off and smooth on the skin appear yellow. Quality hard and difficult to break, fracture surface rough fibrous. Yellow-white cross-section to form a layer of clear. Air pungent, very bitter taste. Flavescens piece oblique slices, shapes and sizes, round or oblong oblique, long 2 to 5 cm, width 1 to 1.5 cm, thickness 2 to 5 mm. Quality hard, yellowish white cut surface, there is ring ring, xylem for the radiation pattern. To tidy, yellow and white color, bitter taste are preferred. Are produced around the country, Shanxi, Hubei, Henan, Hebei yield larger.
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Microscopic identification
Root cross-section: cork layer of cork cells in multiple columns. Cortex narrow. Phloem scattered with fiber bundles, fiber bundles around the cell containing calcium oxalate crystals to form a crystal fiber, crystal cell wall of wood of uniform thickness; ray wide and clear, almost to the formation of cork not a ring. Xylem radially arranged; wood fiber for crystal fiber. Powder: yellow. ① starch granules round or oblong, diameter 4-22μm, Umbilical point crack-like, laminated looming large grain; complex composed of grain particles from the 2-12 minutes. ② fiber slender, straight or slightly curved, diameter 11-27μm, the wall is very thick, non-wood based, colporate obvious, cell-line. Fibers around the cells with calcium oxalate crystals to form a crystal fiber, with no increase in crystal cell walls of wood of uniform thickness; calcium oxalate crystal class of two cone-shaped, diamond or surface shape. ③ bordered pits vessel diameter 27-126μm, closely arranged bordered pits, and some number of lines connected linear orifice. Also netted catheter. ④ round or class of thin-walled rectangular cells, walls thicker, and some showed uneven Pente-like, non-wood based, large and small pits, some integrated field pits, and some cell-crystal with a small needle. ⑤ View class polygonal cork cells, anticlinal walls are shaped pits were intermittent, irregular surface of small cracks. Another occasional stone cells.
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Each paper
1. "Ben Cao Yan Yi Addendum": flavescens, could fill Jun chi, or have the Erzhi waist severe, because of gas down and not rise too, non-injured kidney that also. The wind rule active, the status of wind-heat rash almost fine. 2. "Compendium of Materia Medica": flavescens, Treats of the bitter cold, able to kidney, whichever is hard cover dampness, cold than hot too. Heat the wind, wet insects, so pesticides can rule the wind. However, the weak and renal water-fire winner with the appropriate, if Huoshuai fine cold, lack of real dollars, and also high-the person is not available. Zhang Yiyun from now, all drugs are poisonous, though licorice, Sophora, not that the drugs do not, Jiufu the flavors of the property of their dirty, there must be increasing the risk of side wins gas, various drugs are natural, when the contact classes and academics length of the can also, as diet is no different. Then press the "Historical Records" cloud, Taicang public health Chunyu Yi Qi Dafu disease dental caries, moxibustion left hand Yangming clock to rinse flavescens soup at three liters, and out of carefully wind, five or six days more, which is also hot and humid atmosphere of insecticide to whichever meaning. 3. "Materia Medica words": Yaofei Cheng Yun, matrine, chills and purging fire, dampness to the insects of the drug also. Flavescens previous kidney yin tonic that its very absurdity of. Cover the drug is bitter gas fishy, dry shade things, bad hard foul clothing, but kidney and wet real winner should be the fire; if Huoshuai fine cold, lack of Yuanyang, and high-person, empty stomach qi is weak, should not have too. Conditions have Jiufu Erzhi waist severe, because of their expertise rather than falling up, real harm to the kidneys that also, how the power almost a kidney yin tonic? . 4. "Materia Medica hundred recorded": flavescens, cures heart by the fire, and Coptis similar function. But the fire of berberine was similar to the heart of many like to Xinfu flavescens fire the small intestine for many, places the smell of berberine clear, but the smell flavescens cloud also. Fill in the word press, but also whichever is hard to dry the spleen of righteousness. 5. "Changsha drug solution": "Golden" Sophora soup, Fox government were puzzled loss at the lower part, to the liver reinforcement, the first negative reinforcement of those cases together, the soil wet wood collapse, Yu and the heat, chemical and biological pest NI , erosion in the former shade, Sophora heat away wet, sore and insecticide treatment also. Angelica flavescens Fritillaria pills, pregnancy, treatment with the urine is difficult, wet wood to soil subsidence, Yu and heat, can not discharge, heat transfer bladder, which will be very difficult, Sophora is also clear heat and Tonglin astringent. 6. "Materia Medica of justice": flavescens, large hard Big Chill, fever drawdown, cleaned up the wet the fire, and its efficacy and Qin, even, gentian are similar, but the pain was even worse flavescens, the dry You Lie, it can heat to kill the worms born, compared with Qin, even the power of strong interest. Neighbor is not to into the decoction, hard cover irrelevant to an aversion to the bitter service, also suspected of the Jun Li without fear also. However, the wind evil skin disease virus, non-this is not removed, but that modern people used to wash sores, too due to fear of choking and food waste ears. 7. "Shen Nong Ben Cao Jing": the main confidant Results gas, Zheng Jia accumulation, jaundice, drowning more than Lek, by water, in addition to boils, fill in the eyesight only tears. 8. "Doctors do not record": Liver courage, On the five internal organs, Dingzhi Yi Jing, Lee Jiuqiao, in addition to V hot intestinal bleach, thirst, sober, red yellow urine, the lower part of ulcer treatment and malignant sore, flat Stomach, it is preferable. 9. Hongjing: evil drink Jiuzi patients suffering from scabies who also served in addition, cover to insecticide. 10. "Medicinal": the wind toxic heat treatment, skin sore muscle irritability, red skin disease eyebrow off, the main exception of the hot drowsiness, governance belly Leng Tong, the evil abdominal pain, in addition to the body, nausea, governance confidant accumulation. 11. "Tang Materia Medica": governance tibia acid, treatment and bad insects. 12. "Japan Hanako Materia Medica": Malnutrition kill insects. Fried with smoke out the end of the meal drink, cure intestinal wind and heat of blood dysentery. 13. "Pearl sac": dewetting. 14. "Southern Yunnan Materia Medica": cooling, antipyretic drugs, scabies skin disease, sore pus nest. Treatment of skin itching, ringworm sores in blood, naughty white dust, winds, intestinal blood, blood in the stool. Xiaofeng, swelling drugs, sputum poison. 15. "New Materia Medica": dampness, wins heat, cure wet dream Hua Jing.
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Pharmacology
1. Anti-tumor effects: matrine has antitumor activity, mice were injected intraperitoneally 500μg.d group 2mo survival rate was 40%, while the control group all died within 23 days. Oxymatrine is no effect on this. Matrine decreased in vitro murine peritoneal macrophage tumor cell proliferation inhibitory effect of P815. Sophocarpine (Sophocarpine) have anticancer activity in experimental mice on the S-180, U-14.ECA, L and other strains showed significant tumor inhibition. Matrine, oxymatrine, Sophocarpine and different ratio of A, B, C base on the S-180 solid tumor were different degrees of inhibition, the inhibitory rate of each monomer in the 35 Alkaloid %, and by the different ratio of C alkaline dose 113mg / (kg · d), the continuous 10-day intraperitoneal injection tumor rate was 61.38%, 23.5% increase over total alkaloids, with matrine alone, compared There were significant differences (P <0.01). Matrine on chronic myeloid leukemia in peripheral blood progenitor cells more than the colony to produce a significant rate of the inhibitory rate of 0.76, the best inhibitory concentration of 100mg / L. Flavescens decoction role in the proliferation of human promyelocytic leukemia cells in a dose 8mg/ml, can significantly induce leukemia cells to monocyte-macrophage cell differentiation. 3. On the cardiovascular system: 1/4LD50 the intravenous injection of matrine and oxymatrine significantly against aconitine and chloroform - adrenaline-induced arrhythmias in rats; intraperitoneal injection was significantly smaller against chloroform-induced rat ventricular fibrillation, and arrhythmias induced by aconitine increased the amount required against barium chloride-induced arrhythmia in rats and rat anterior descending coronary artery ligation-induced arrhythmia. To the intravenous injection of 30mg/kg oxymatrine rabbits, adrenaline-induced arrhythmia shorten recovery time, an average reduction of 43% of drug treatment, prophylaxis average reduction of 22%. Sophocarpine 42mg/kg intravenous calcium chloride can be induced in mice against ventricular arrhythmias and aconitine induced rat arrhythmia; intravenous injection l6mg/kg can improve the Bus wow premature beat and cardiac arrest due to rise to the rabbit required amount, but also against coronary artery occlusion - reperfusion induced arrhythmias in dogs, but not against the calcium chloride - acetylcholine-induced mice atrial fibrillation (flutter) and chloroform - adrenaline induced arrhythmias in rabbits. Intravenous injection of l / 5 LD50 of sophoridine (11mg/kg) for the prevention or treatment of aconitine induced rat arrhythmia husband often, but also can increase the guinea pigs for a cause of arrhythmia in Pakistan wow the tolerated dose, to prevent barium chloride and calcium chloride induced arrhythmia. 1 / 10 LD50 dose (5mg/kg) significantly shorten the time of epinephrine arrhythmia caused by rabbits, and the long duration of action than quinidine. Also improve left ventricular fibrillation threshold of electroluminescence, and with increasing intravenous doses to improve, but also dose-related reduction in chloroform or carbon tetrachloride in mice induced ventricular fibrillation rate, and against carbon tetrachloride - arrhythmias caused by adrenaline in rabbits. Sophora alkaloids have dilation of blood vessels and the acute myocardial ischemia. In anesthetized rabbits can cause significant antihypertensive effect, the general blood pressure 20mmHg or so, for 2-3 minutes to return to normal; on isolated rabbit ear blood vessels caused by the expansion immediately, and continued for 10 minutes; on the heart can be extended acute hemorrhagic The arrest time, extend the time for 7 minutes; of pituitrin acute myocardial ischemia induced significant protective effect. Oxymatrine increased contractile force of rabbit heart, and a good dose - response relationship, 9μm does not affect cardiac excitability, but shorten the functional refractory period; reduce the autonomy of the left atrium induced by epinephrine threshold concentration; slow right atrium automatic rhythm, and reduce right atrial CaCl2 on the positive frequency effect. Toxic amount of (360μm) can reduce cardiac contractility and excitability. Oxymatrine 50μmol / L could antagonize the positive frequency of isoproterenol effect. The oxymatrine (100μmol / L) in cultured myocardial cells is low (high) concentration allows to α (β) receptor-mediated negative (positive) effect of frequency. Matrine can slow down the guinea pig right atrial automatic frequency, increasing right atrial contractile force and reduced left atrial MDF (the maximum driving frequency), and dose-dependent; the negative frequency and negative inotropic effects were MDF linear correlation. Aconitine induced matrine can inhibit the self-regulatory role of left atrium induced by aconitine or extended automatically slow down the rhythm of latency and initial frequency; also can increase the wow bar for arrhythmia induced and epinephrine in guinea pig right atrium guinea pigs induced by left atrial injection of the threshold concentration of self-discipline, and wow Pakistan because of the positive inotropic effect can enhance the effect. Matrine Ca2 + channel blocker can be verapamil (1μmol / l) significantly inhibited, and inhibition of smooth muscle than cardiac, suggesting a positive inotropic effect of matrine may be related to activation of Ca2 + channels. Matrine can increase cAMP levels in rat plasma levels and lower cMP of cAMP and cGMP content in cardiac tissue had no significant effect. Sophoridine can increase cAMP levels in rat plasma and myocardial tissue cAMP content. Oxymatrine 50μmol / L and 250μmol / L mitomycin C on cultured myocardial cell injury caused by lactate dehydrogenase levels were significantly higher inhibitory effect, and can reduce oxygen and glucose deprivation caused by the myocardial cell damage , but chlorpromazine caused no effects on myocardial cell injury. Intramuscular injection in mice was significantly prolonged oxymatrine with allogeneic cardiac graft survival role and enhance its role with the dose increased. Purification of total flavonoids 125-250μg/ml, can slow down the cell mass of cultured neonatal rat cardiomyocytes the frequency of spontaneous beating, and to fight against myocardial cell mass due to spontaneous and induced beat Pakistan wow rhythm disorders. Purification of total flavonoids of mouse ventricular fibrillation caused by inhalation of chloroform significant role in the confrontation, the LD50 was 23.9 ± 1.1g/kg, therapeutic index is 3.56. Intravenous injection to rabbits and purification of total flavonoids 8g 30g/kg ,30-60 minutes, significantly against the chloroform - adrenaline induced arrhythmia. Completely against the rate of 40% and 70%. Intravenous purification of total flavonoids 20-40g/kg, on intravenous aconitine induced arrhythmia treatment are obvious. The first effective treatment rate was 63%, the second treatment was 84% effective. Matrine injection in rats significantly against aconitine, barium chloride-induced arrhythmia and coronary artery ligation in anesthetized rats given intravenous 30g/kg purification of total flavonoids and 60g/kg, showed significantly negative self- role, the role of negative frequency and negative conduction. These effects increased with the dose increased. 5. Stability and function: Sophora alkaloids 50-100mg/kg could inhibit the free movement of mice; 400mg/kg in mice significantly inhibited passive; 100-200mg/kg alone can inhibit aggressive behavior in mice of the European struggle; Sophora Alkaloids 25-40mg/kg and Dongmian Ling (5mg/kg) combination, can be induced loss of righting reflex ,100-200mg / kg matrine alkaloids can significantly enhance 0.5mg/kg reserpine in mice Inhibition of spontaneous activity; matrine alkaloids 50-200mg/kg with intraperitoneal injection of subthreshold dose of pentobarbital sodium 20-25mg/kg combination, can be induced to sleep; respectively with thiopental (intraperitoneal injection, 40mg/kg), chloral hydrate (intraperitoneal injection, 200mg/kg) combined, can significantly enhance its central inhibition. Also clearly against the central stimulant amphetamine (intraperitoneal injection ,4-6mg / kg) and caffeine (50mg/kg)-induced psychomotor excitement; flavescens alkaloids on strychnine and pentylenetetrazol-induced seizures not only non-combat role, but to enhance and increase the animal seizure deaths; flavescens alkaloids alone a mild analgesic effect, and threshold dose of morphine combination, can significantly increase the percentage of its analgesic. 6. Anti-allergic effects: matrine can reduce the release of allergy mediators, as immunosuppressive agents, the inhibition of 50% T cell proliferation in a concentration 0.55-0.56mg/ml; inhibition of IL-2 production at a concentration of 0.1mg/kg . 7. Immunosuppressive effects: matrine, oxymatrine in 1 / 5 LD50 doses inhibit immune function in mice. Rabbits, rats injected 150mg/kg or 100mg/kg oxymatrine on passive and active cutaneous anaphylaxis were significantly reduced, and the rabbit serum IgE antibody formation was significantly inhibited. Intraperitoneal injection of oxymatrine 200mg/kg · d, a total of 21 days, allergic reaction in mice caused rapid on_set_ of death has a protective effect. 8. Other effects: intramuscular injection can significantly against oxymatrine croton oil, carrageenan (rat) and glacial acetic acid (mice) induced exudative inflammation. Rabbit gavage, subcutaneous injection, intravenous injection, intraperitoneal injection and intramuscular matrine decoction, matrine and matrine injection have a diuretic effect, sodium chloride content in urine was significantly increased. Flavescens 50% methanol extract with anti-ulcer effect of hydrochloric acid caused by ethanol, the active ingredient flavescens ketone (Kurarinone). In addition, both in vivo antibacterial effect of matrine, chloramphenicol considerable strength in vivo, In vitro anti-trichomonad extract alcohol effect similar to the strength and hops.
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Chinese Pharmacopoeia 2005 Edition
Name: Flavescens Pinyin: Kushen English name: RADIX SOPHORAE FLAVESCENTIS Base of the original: This product legumes Sophora Sophora flavescens Ait. Dry root. Spring and autumn dredging, removing roots and small branch roots first, wash, dry, or take advantage of fresh slices and dried. Characters: This product is elongated cylinder, the lower branches are often long and 10-30cm, diameter of 1-6.5cm. Surface brown or gray brown, with longitudinal wrinkles and transverse lenticels long, thin outer, more broken anti-roll, easy peeling, flaking at the show yellow and smooth. Hard, difficult to break, fibrous cross-section; slice thickness of 3-6mm; section yellow-white, with texture and radial cracks, some with concentric vascular bundles of the ring shaped or irregular scattered row. Gas micro, very bitter taste. Identification: (1) cross-section of this product, add a few drops of sodium hydroxide test solution, which was orange-red of Cork, changed to blood red, long home does not disappear. Xylem does not show the color reaction. (3) take oxymatrine reference substance, add ethanol made from 0.2mg per 1ml of solution containing, as the reference solution. According to thin layer chromatography (Appendix Ⅵ B) test, to learn identification 〔〕 (2) under the test solution and the reference solution of the 4μl, respectively, at the same point with 2% sodium hydroxide solution prepared silica gel G thin laminates, and the chloroform - methanol - ammonia solution wave (5:0.6:0.3) 10 ℃ lower placed the following solution as the agent, started out, dry, followed by spray with bismuth potassium iodide test solution and ethanol test solution of sodium nitrite. Test products for chromatography, chromatography with reference substance corresponding position, was the same orange spots. Check: Determination of water according to water (the first method appendix Ⅸ H) measurement, not over 11.0%. 8.0% of total ash may not have (Appendix Ⅸ K). Acid insoluble ash not more than 1.5% (Appendix Ⅸ K). Extract: Determination of water-soluble extract according to under the cold soak method (Appendix Ⅹ A) the determination of not less than 20.0%. Determination: High performance liquid chromatography (Appendix Ⅵ D) determined. Chromatographic conditions and system suitability test for amino-bonded silica as a filler; with acetonitrile - ethanol -3% phosphoric acid (80:10:10) as mobile phase: detection wavelength was 220nm. Number of theoretical plates oxymatrine peak should not be less than 2000. Preparation of control solution Weigh matrine precision reference substance, reference substance oxymatrine amount, and each with acetonitrile - ethanol (80:20) dissolved in 1ml into each containing matrine 0.05mg, oxidation flavescens alkaline solution of 0.15mg. That is, too. Preparation of the test solution to take the product powder (sieve through III) of about 0.3g. Precision that _set_, and placing a stopper conical flask, add concentrated ammonia solution 0.5ml, precision add chloroform 20ml, Mesa, said that given the weight, ultrasound treatment (power 250W, frequency of 33kHz) 30 minutes, let cool, then said that given the weight of the city make up the loss with the weight of chloroform, shaking, filtration. Precise amount of filtrate added 5ml, through the neutral alumina column (10-200 mesh, 5g, diameter 1cm), followed by chloroform, chloroform - methanol (7:3) 20ml elution of the collected eluent recycling solvents to dry, the residue allows the dissolved amount of ethanol, and transferred to a 10ml volumetric flask, add dilute ethanol to the mark, shake, that was. Determination of the reference solution, respectively, the precise drawing of the test solution with 5μl 5-10μl, into the liquid chromatograph to measure, that is, too. This product calculated on dry goods, including matrine (C15H24N2O2) and oxymatrine (C15H24N2O2) the total amount of not less than 1.2%. Processing methods: Remove residual root head, size of the separated wash. When immersed to about two-thirds through, run through, cut into thick slices, and dry. Nature: Bitter, cold. Meridian: The heart, liver, stomach, large intestine, the bladder.
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Chinese herbal medicine
RADIX SOPHORAE FLAVESCENTIS
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Chinese Pharmacopoeia 2000
Flavescens Pinyin: Kushen English name: RADIXSOPHORAEFLAVESCENTIS Page number: 2000 edition -161 This product legumes flavescens SophoraflavescensAit.'s Dried root. Spring and autumn excavation, in addition to Head and a small branch to the root of the root, wash, dry, or take advantage of fresh slices and dried. 【Properties】 The product elongated cylindrical, the lower branches are often long and 10 ~ 30cm, diameter of 1 ~ 2cm. Surface gray Brown or brownish yellow, with longitudinal wrinkles and transverse long lenticels, outside the thin, multi-burst anti-roll, easy to peel off, peel off at the show yellow, Smooth. Hard, difficult to break, fibrous cross-section; slice thickness 3 ~ 6mm; section yellow-white, with a radial texture and crack Gap, some visible concentric ring pattern. Gas micro, very bitter taste. Identification (1) cross-section of this product, add a few drops of sodium hydroxide test solution, which was orange-red of Cork, the gradient for the blood Red, long home does not disappear. Xylem does not show the color reaction. (2) to take this product meal 1g, plus ethanol solution containing 0.5% hydrochloric acid 20ml, refluxed 1 hour, filtration, the filtrate plus Ammonia solution to neutral, evaporated and the residue add 10ml of 1% hydrochloric acid solution Dissolve, filtration, take three tubes split filtrate In a test solution of iodine of potassium bismuth to produce red-brown precipitate; a test solution of potassium iodine of mercury to produce yellow-white Shen Lakes; another tube of iodine test solution add potassium iodide to produce brown precipitate. (3) to take this product powder 0.5g, add methanol 10ml, heat reflux for 10 minutes, filtration. Filtrate obtained 1ml, home test tube, Add a small amount of magnesium powder with 3 to 4 drops of hydrochloric acid, heating, was red; In another point on the filter paper the filtrate, sprayed with 5% aluminum chloride, ethanol Solution, drying, home UV light (254nm) was observed, which was yellow-green fluorescence. (4) to take this product powder 0.5g, add chloroform 25ml, strong ammonia solution 0.3ml, overnight, filtration, the filtrate evaporated Dissolve the residue 0.5ml chloroform as the test solution. In another oxymatrine and Sophoridine reference substance, add ethanol Each containing 0.2mg per 1ml into a mixed solution, as the reference solution. According to thin layer chromatography (Appendix Ⅵ B) test, Draw the two solutions of the 4μl, respectively, at the same point with 2% sodium hydroxide solution prepared silica gel G thin- Benzene - acetone - methanol (8:3:0.5) as the agent, to start developing from about 8cm, removed, dried, and then with toluene - Ethyl acetate - methanol - water (2:4:2:1) 10 ℃, after placing the upper solution of the following as the agent, started from the above development, Removed, dried, and then click sprayed with test solution of potassium bismuth iodide and sodium nitrite, ethanol test solution. Chromatography in the test, with the reference substance Chromatography corresponding position, was the same two orange spots. Check】 【not have total ash 6.0% (Appendix Ⅸ K). Acid insoluble ash not more than 1.5% (Appendix Ⅸ K). 【Assay meal of this product of about 2g [while other goods from the coarse determination of water (the first method appendix Ⅸ H)], Precision that _set_, and placing a stopper conical flask, add chloroform precision 50ml, strong ammonia solution 1ml, Mesa, said that given weight, always shaking, After 24 hours, then said that given the weight, with chloroform complement the weight loss, shaking, filtration, precise amount of filtrate added 25ml, Home evaporating dish, evaporated and the residue allows the dissolved plus ethanol, transferred to a 5ml volumetric flask, and dilute to volume, shake for As the test solution. Learn another vacuum drying to constant weight of phosphorus pentoxide matrine appropriate reference substance, accurately weighed, add no Ethanol made from water containing 0.5mg per 1ml of solution, as the reference solution. According to thin layer chromatography (Appendix Ⅵ B) test, precision Absorb the test solution 3 ~ 10μl, the reference solution 2μl and 4μl, were crossing the same silica gel G thin-layer board Benzene - acetone - ethyl acetate - concentrated ammonia solution (2:3:4:0.2) as the agent, started out, dried, sprayed with test solution of potassium bismuth iodide, Then sprayed with a small amount of 5% sodium nitrite solution to the spot color definition, the same size in the thin layer covering the glass plate, surrounded by Strapping, place 2 hours later, according to thin layer chromatography (TLC Annex Ⅵ B) scanning, wavelength: λ <[S]> = 480nm, λ <[R]> = 650nm, measurement of the test and reference substance absorption integral absorption integral, calculation, that is, too. This product calculated on dry goods, including matrine (C15H24N2O) not less than 0.080%. 【】 To remove residual processing and first, size separated, washed, soaked to about two-thirds through, the run through, cut into thick slices, Dry. 【】 Meridian of taste and bitter cold. The heart, liver, stomach, large intestine, the bladder. 【Functions and Indications】 heat dampness, insecticide, diuretic. For hot dysentery, blood in the stool, jaundice urinate, Chibai vaginal discharge, Yin Yang Yin swelling, eczema, eczema, skin itching, scabies, leprosy; external treatment trichomonas vaginitis. 【Usage and Dosage 4.5 ~ 9g. External use, Jiantang wash the affected area. 【Note】 not and with the use of Veratrum. 【Storage】 home and dry place.