germ : animal : marine products : medicine : disease prevention > Hydrochloride Ciprofloxacin Suppository
Contents
No. 1
  Ciprofloxacin (alias: C norfloxacin, noted Xin Fu, ciprofloxacin, noted the complex Huan, Supresoft Spirit)
  ciprofloxacin (cifran, ciproxin, ciflox)
  [Action and Uses
  This product is the third generation of synthetic quinolone antibacterial drug with broad-spectrum antimicrobial activity, bactericidal effect, compared with nearly all antibacterial activity against bacteria, norfloxacin and enoxacin 2 to 4 times stronger for Enterobacteriaceae , Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, Staphylococcus aureus has an antibacterial effect.
  The main clinical respiratory tract caused by susceptible strains used, urinary tract, gastrointestinal tract, skin and soft tissue infections and cholecystitis, cholangitis, otitis media, sinusitis, gonococcal urethritis. Methicillin-resistant Staphylococcus aureus (mrsa) infections caused by vancomycin-intolerant, using this as one of the optional combination.
  Dosage and Usage]
  Oral, adult 0.2g / time, 2 to 3 times / day; also usage of 0.5g ~ 0.75g / second, 1/12 hours. Infusion, 0.1g ~ 0.2g / times, 2 times / day, can dilute saline or glucose injection, infusion time of less than 30 minutes.
  [Preparation and specifications
  1 tablet: Each piece is labeled amount calculated by ciprofloxacin 250mg; 500mg; 750mg (amount of salt monohydrate was 291,582, or 873mg).
  2 Injection: Each 100mg (50ml); 200mg (100ml) (127.2 respectively containing lactate or 254.4mg).
  [Side effects]
  A common nausea, abdominal pain and diarrhea area.
  2 headache, irritability, and skin rash.
  3 pairs of this allergy is disabled, pregnant women, lactating women and children with caution.
Translated by Google
No. 2
  Ciprofloxacin (alias: C norfloxacin, noted Xin Fu, ciprofloxacin, noted the complex Huan, Supresoft Spirit)
  Ciprofloxacin (Cifran, Ciproxin, Ciflox)
  Pharmacology and Toxicology
  This product is a broad-spectrum antibacterial activity, especially aerobic gram-negative bacilli high antibacterial activity of these bacteria have a good antibacterial effect in vitro: Most intestinal bacteria Bacillus families, often for multi-drug resistant also has antibacterial activity, Penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae enzyme production and Moraxella were highly antimicrobial activity. Pseudomonas aeruginosa and other Pseudomonas species of most strains with antibacterial activity. But poor antibacterial activity against anaerobes.
  Ciprofloxacin is a fungicide, by acting on bacterial DNA gyrase A subunit, inhibition of DNA synthesis and replication resulting in bacterial death.
  [Action and Uses
  This product is the third generation of synthetic quinolone antibacterial drug with broad-spectrum antimicrobial activity, bactericidal effect, compared with nearly all antibacterial activity against bacteria, norfloxacin and enoxacin 2 to 4 times stronger for Enterobacteriaceae , Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, Staphylococcus aureus has an antibacterial effect.
  The main clinical respiratory tract caused by susceptible strains used, urinary tract, gastrointestinal tract, skin and soft tissue infections and cholecystitis, cholangitis, otitis media, sinusitis, gonococcal urethritis. Methicillin-resistant Staphylococcus aureus (MRSA) infections caused by vancomycin-intolerant, optional FDA as one combination.
  Dosage and Usage]
  Oral, adult 0.2g / time, 2 to 3 times / day; also usage of 0.5g ~ 0.75g / second, 1/12 hours. Infusion, 0.1g ~ 0.2g / times, 2 times / day, can dilute saline or glucose injection, infusion time of less than 30 minutes.
  [Preparation and specifications
  1 tablet: Each piece is labeled amount calculated by ciprofloxacin 250mg; 500mg; 750mg (amount of salt monohydrate was 291,582, or 873mg).
  2 Injection: Each 100mg (50ml); 200mg (100ml) (127.2 respectively containing lactate or 254.4mg).
  [Side effects]
  A common nausea, abdominal pain and diarrhea area.
  2 headache, irritability, and skin rash.
  3 pairs of this allergy is disabled, pregnant women, lactating women and children with caution.
Translated by Google
Chinese Pharmacopoeia 2005 edition
  Name:
  Ciprofloxacin
  Pinyin:
  Huanbingshaxing
  English name:
  Ciprofloxacin
  Properties:
  This product is white to light yellow crystalline powder; almost odorless, bitter taste.
  The product is dissolved in acetic acid, very slightly soluble in ethanol and chloroform, almost insoluble in water.
  Identification:
  (1) In the determination of the chromatogram records, the test solution peak retention time should be consistent with the reference solution peak retention time.
  (2) The product of the infrared absorption spectrum should be consistent with the control of the map (spectral _set_ 979 Figure).
  Check:
  Crystalline little of this product, according to inspection (Appendix Ⅸ D), should be specified.
  Clear solution should take this product with color 0.1g, after adding 0.1mol / L hydrochloric acid solution 10ml dissolved, the solution should be clarified (Appendix Ⅸ B) colorless; such as color, with yellow or yellow-green on the 4th standard colorimetric solution ( Appendix Ⅸ A first method), not deeper.
  Fluoroquinoline acid to remove the goods, plus 0.1mol L hydrochloric acid solution / solution made from 10mg per 1ml, as the test solution; Another fluoroquinoline acid reference 5.0mg, home 50ml volumetric flask, add 6mol / L ammonia solution 0.05ml with water to dissolve and dilute to the mark, shake, the precise amount of the check amount, diluted with water containing 0.03mg per 1ml of solution as the reference solution; take the two solutions 1ml, mixing, as the mixed solution. Thin layer chromatography (Appendix Ⅴ B) test, to learn the three solutions 5μl, respectively, in the same gel GF254 TLC plate, into ammonia for about 15 minutes, then dichloromethane - methanol - concentrated ammonia solution - acetonitrile (4:4:2:1) as the agent, started to dry, UV light (254nm) under inspection machine. Fluoroquinoline spots mixed acid and ciprofloxacin should be separated completely obvious solution. The test solution and the reference solution such as significant impurities main spots corresponding spots, the color of the explicit reference solution with the main spots, not deeper (0.3%).
  Take some related substances, with the 7% phosphoric acid solution 0.2ml dissolved, add the mobile phase and dilute solution made of about 0.5mg per 1ml, as the test solution, the precise amount of the check amount, made with a mobile phase of quantitative 1μg per 1ml solution, as a control solution. According to determination of chromatographic conditions under, take control solution 50μl into the liquid chromatograph, adjust the sensitivity, the principal component of chromatographic peak height of approximately 20% of full scale, the test solution and control solution for the precise amount of each 50μl, were injected into the liquid chromatograph, record the chromatograms to the main component peak retention time. Chromatogram of the test solution if the impurity peak, peak area no larger than a single impurity control solution peak area (0.2%), and the impurity peak area (or any area less than 0.05 times the control solution peak peaks negligible) shall not be greater than control solution peak area of ​​2.5 times (0.5%).
  Drying of this product to phosphorus pentoxide as a desiccant, according to the drying method (Appendix Ⅷ L) was measured at 120 ℃ vacuum dried for 6 hours, less weight loss should not exceed 1.0% weight loss was measured.
  Chi residues of this product 1.0g, _set_ in a platinum crucible, according to inspection (Appendix Ⅷ N), no residue left over 0.1%.
  Heavy metals residue on ignition key under the residue left over, according to inspection (Appendix Ⅷ H), containing heavy metals must not exceed twenty millionths.
  Determination:
  High performance liquid chromatography (Appendix Ⅴ D) measurement.
  Chromatographic conditions and system suitability test octadecylsilane bonded silica as a filler; to 0.05mol / L citrate solution - acetonitrile (82:18) adjusting the pH to 3.5 with triethylamine as the mobile phase; flow rate per minute lml; to temperature 30 ℃; detection wavelength of 277nm. Number of theoretical plates ciprofloxacin peak of not less than 2000. Ciprofloxacin peak separation between adjacent impurity peak should meet the requirements.
  Determination To about 25mg, accurately weighed, _set_ 50ml volumetric flask, with the 7% phosphoric acid solution 0.2ml dissolved, add the mobile phase and dilute to the mark, shake, the precise amount of 10μl into the liquid chromatograph, record the chromatograms Figure; Another ciprofloxacin reference, the same method, the external standard method to calculate the peak area for the test product Cl7H18FN3O3 content.
  Storage:
  Shading, sealed and stored.
  Preparation:
  Ciprofloxacin Sodium Chloride Injection
  Western medicine Category:
  Medicine (including chemical, biochemical drugs, antibiotics, radioactive drugs, pharmaceutical excipients))
  Chemical composition:
  This product is 1 - cyclopropyl-6 - fluoro -1,4 - dihydro - 4 - oxo-7 - (1 - piperazinyl)-3 - quinoline carboxylic acid. Calculated on the anhydrous, 98.5% with C17H18FN3O3 should - 102.0%.
  Molecular formula and weight:
  C17H18FN3O3 331.34
  Pharmacological effects:
  Quinolones
Translated by Google
Drug Encyclopedia
  Drug Name
  (Including trade name, generic name) Ciprofloxacin Dosage (1) Oral Adult 1 250mg, 1 to 2 times, severe amount may be doubled. However, the maximum amount should not exceed 1 1500mg. Renal dysfunction (creatinine clearance rate of less than 300ml / min) should be reduced by the amount of clothes. (2) intravenous infusion: 1 100 ~ 200mg, 1 to 2 times, pre-diluted with isotonic sodium chloride or dextrose injection, infusion time of less than 30 minutes. Adult, general infection 400 ~ 500mg / d, 2 times to give; severe, 800 ~ 1000mg / d, 2 times to give. Pharmacological effects similar antibacterial spectrum and norfloxacin for E. coli, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, Staphylococcus aureus, Bacteroides fragilis, such as the minimum inhibitory concentration (MIC90) is 0.008 ~ 2 μg / ml, was significantly better than other similar drugs, and cephalosporins, aminoglycosides and other antibiotics, anti-β-lactams or gentamicin resistant bacteria are very effective. / / / With broad-spectrum antimicrobial effect on the activity of virtually all species than norfloxacin, enoxacin 2 to 4 times stronger, and quite ofloxacin, norfloxacin same mechanism of action.
  Indications caused by susceptible strains suitable respiratory tract, urinary tract, digestive tract, biliary tract, skin and soft tissue, pelvic, eyes, ears, nose, throat infections raise the site. With ofloxacin. Intravenous administration can be used to treat severe infections, such as E. coli-induced sepsis, severe lung infection and abdominal, biliary tract infections. Adverse reactions with norfloxacin, oral doses larger, more common gastrointestinal reactions.
  Formulation tablet: Each tablet labeled amount calculated by ciprofloxacin is 250mg, 500mg; 750mg (salt monohydrate were respectively 291,582 or 873mg); Injection: Each 100mg (50ml); 200mg (100ml ) (127.2 respectively containing lactate or 254.4mg). Note (1) severely inhibit the normal metabolism of theophylline, the combination can cause serious adverse reactions of theophylline should be monitored plasma concentration of theophylline, caffeine, warfarin may have the same impact, should be noted. (2) may be taken with food, but antacids inhibit the absorption of this product, you should avoid the same service. (3) pregnant women, lactating women and minors should not use this product.
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English Expression
  1. :  Ciprofloxacin Hydrochloride Cream,  Cifran,  Ciflox,  Ciproxin,  Ciprofloxacin Ophthalmic Ointment,  Ciprofloxacin Lactate Vaginal Effervescent Tablets,  Ciprofloxacin Lactate Injection,  Ciprofloxacin Lactate for Injection,  Ciprofloxacin Lactate Eye Drops,  Ciprofloxacin Hydrochloride Tablets,  Ciprofloxacin Hydrochloride Ointment,  Hydrochloride Ciprofloxacin Suppository,  Ciprofloxacin Hydrochloride Capsules,  Ciprofloxacin Hydrochloride-Bikai Pharm,  Ciprofloxacin Hydrochliride Ear Drops,  Ciprofloxacin-Huajin Pharm,  Ciprofloxacin-Baiyunshan,  Ciprocin,  Ciprobay,  Ciplox,  Ciprofloxacin
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